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. 1987 Sep;55(9):2317–2319. doi: 10.1128/iai.55.9.2317-2319.1987

Specific effect of estradiol on the genital mucosal antibody response in chlamydial ocular and genital infections.

R G Rank, A L Barron
PMCID: PMC260701  PMID: 3623706

Abstract

Estradiol treatment of female guinea pigs was found to alter the course of genital, but not ocular, infection with the chlamydial agent of guinea pig inclusion conjunctivitis. Immunoglobulin G (IgG) and IgA responses in genital secretions of genitally infected animals were delayed by estradiol treatment, but neither response in the eye resulting from either ocular or genital infection was affected. However, the appearance of IgG in the genital tract after ocular infection was markedly inhibited in estradiol-treated guinea pigs.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barron A. L., White H. J., Rank R. G., Soloff B. L. Target tissues associated with genital infection of female guinea pigs by the chlamydial agent of guinea pig inclusion conjunctivitis. J Infect Dis. 1979 Jan;139(1):60–68. doi: 10.1093/infdis/139.1.60. [DOI] [PubMed] [Google Scholar]
  2. Bose S. K., Goswami P. C. Enhancement of adherence and growth of Chlamydia trachomatis by estrogen treatment of HeLa cells. Infect Immun. 1986 Sep;53(3):646–650. doi: 10.1128/iai.53.3.646-650.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Caldwell H. D., Kromhout J., Schachter J. Purification and partial characterization of the major outer membrane protein of Chlamydia trachomatis. Infect Immun. 1981 Mar;31(3):1161–1176. doi: 10.1128/iai.31.3.1161-1176.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Ellens D. J., Gielkens A. L. A simple method for the purification of 5-aminosalicylic acid. Application of the product as substrate in enzyme-linked immunosorbent assay (ELISA). J Immunol Methods. 1980;37(3-4):325–332. doi: 10.1016/0022-1759(80)90318-x. [DOI] [PubMed] [Google Scholar]
  5. Levy N. J., Muñoz A., McCormack W. M. Enzyme-linked immunosorbent assay for the detection of antibody to Chlamydia trachomatis and Chlamydia psittaci. J Lab Clin Med. 1983 Dec;102(6):918–925. [PubMed] [Google Scholar]
  6. Pasley J. N., Rank R. G., Hough A. J., Jr, Cohen C., Barron A. L. Effects of various doses of estradiol on chlamydial genital infection in ovariectomized guinea pigs. Sex Transm Dis. 1985 Jan-Mar;12(1):8–13. doi: 10.1097/00007435-198501000-00003. [DOI] [PubMed] [Google Scholar]
  7. Rank R. G., Barron A. L. Humoral immune response in acquired immunity to chlamydial genital infection of female guinea pigs. Infect Immun. 1983 Jan;39(1):463–465. doi: 10.1128/iai.39.1.463-465.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Rank R. G., White H. J., Hough A. J., Jr, Pasley J. N., Barron A. L. Effect of estradiol on chlamydial genital infection of female guinea pigs. Infect Immun. 1982 Nov;38(2):699–705. doi: 10.1128/iai.38.2.699-705.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Sweet R. L., Blankfort-Doyle M., Robbie M. O., Schacter J. The occurrence of chlamydial and gonococcal salpingitis during the menstrual cycle. JAMA. 1986 Apr 18;255(15):2062–2064. [PubMed] [Google Scholar]
  10. Washington A. E., Gove S., Schachter J., Sweet R. L. Oral contraceptives, Chlamydia trachomatis infection, and pelvic inflammatory disease. A word of caution about protection. JAMA. 1985 Apr 19;253(15):2246–2250. [PubMed] [Google Scholar]

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