Abstract
Mice were rendered deficient in B-cell activity by treatment with anti-mu antibody from birth. These animals were then infected intranasally with murine Chlamydia trachomatis (murine pneumonitis agent [MoPn]). They produced neither local nor systemic antibody to MoPn but had intact delayed-type hypersensitivity to MoPn. Anti-mu-treated mice were not significantly more susceptible to primary invasive infection with MoPn than were control mice, and unrestricted multiplication with MoPn did not occur. The dominant immune response controlling this type of infection is not likely to be antibody.
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Selected References
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- Brunham R. C., Kuo C. C., Cles L., Holmes K. K. Correlation of host immune response with quantitative recovery of Chlamydia trachomatis from the human endocervix. Infect Immun. 1983 Mar;39(3):1491–1494. doi: 10.1128/iai.39.3.1491-1494.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Colley D. G. Intradermal immune responses to a schistosomal egg antigen during experimental murine Schistosoma mansoni infection. Proc Soc Exp Biol Med. 1972 Jul;140(3):772–775. doi: 10.3181/00379727-140-36550. [DOI] [PubMed] [Google Scholar]
- Grun J. L., Weidanz W. P. Antibody-independent immunity to reinfection malaria in B-cell-deficient mice. Infect Immun. 1983 Sep;41(3):1197–1204. doi: 10.1128/iai.41.3.1197-1204.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lammert J. K., Wyrick P. B. Modulation of the host immune response as a result of Chlamydia psittaci infection. Infect Immun. 1982 Feb;35(2):537–545. doi: 10.1128/iai.35.2.537-545.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lawton A. R., 3rd, Asofsky R., Hylton M. B., Cooper M. D. Suppression of immunoglobulin class synthesis in mice. I. Effects of treatment with antibody to -chain. J Exp Med. 1972 Feb 1;135(2):277–297. doi: 10.1084/jem.135.2.277. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Maddison S. E., Slemenda S. B., Chandler F. W., Kagan I. G. Acquired immunity in B cell-deficient mice to challenge exposure following primary infection with Schistosoma mansoni. Am J Trop Med Hyg. 1981 May;30(3):609–615. doi: 10.4269/ajtmh.1981.30.609. [DOI] [PubMed] [Google Scholar]
- Rank R. G., Barron A. L. Effect of antithymocyte serum on the course of chlamydial genital infection in female guinea pigs. Infect Immun. 1983 Aug;41(2):876–879. doi: 10.1128/iai.41.2.876-879.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rank R. G., White H. J., Barron A. L. Humoral immunity in the resolution of genital infection in female guinea pigs infected with the agent of guinea pig inclusion conjunctivitis. Infect Immun. 1979 Nov;26(2):573–579. doi: 10.1128/iai.26.2.573-579.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wang S. P., Grayston J. T. Immunologic relationship between genital TRIC, lymphogranuloma venereum, and related organisms in a new microtiter indirect immunofluorescence test. Am J Ophthalmol. 1970 Sep;70(3):367–374. doi: 10.1016/0002-9394(70)90096-6. [DOI] [PubMed] [Google Scholar]
- Williams D. M., Schachter J., Drutz D. J., Sumaya C. V. Pneumonia due to Chlamydia trachomatis in the immunocompromised (nude) mouse. J Infect Dis. 1981 Feb;143(2):238–241. doi: 10.1093/infdis/143.2.238. [DOI] [PubMed] [Google Scholar]
- Williams D. M., Schachter J., Grubbs B., Sumaya C. V. The role of antibody in host defense against the agent of mouse pneumonitis. J Infect Dis. 1982 Feb;145(2):200–205. doi: 10.1093/infdis/145.2.200. [DOI] [PubMed] [Google Scholar]
- Williams D. M., Schachter J., Weiner M. H., Grubbs B. Antibody in host defense against mouse pneumonitis agent (murine Chlamydia trachomatis). Infect Immun. 1984 Sep;45(3):674–678. doi: 10.1128/iai.45.3.674-678.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]