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Journal of the National Medical Association logoLink to Journal of the National Medical Association
. 1998 May;90(5):293–301.

Prevalence of diabetes mellitus and impaired glucose tolerance in a group of urban adults in Nigeria.

S T Olatunbosun 1, P O Ojo 1, N S Fineberg 1, A F Bella 1
PMCID: PMC2608340  PMID: 9617070

Abstract

This survey was undertaken to determine the prevalence of diabetes mellitus and impaired glucose tolerance in a group of urban adults in Ibadan, Nigeria. A total of 998 subjects randomly selected from five main ministries and departments in the Government Secretariat participated in the survey. Each subject was asked to fast overnight and ingested 75 g of glucose dissolved in 250 mL of water after answering a questionnaire. Relevant anthropometric measurements such as weight, height, waist and hip diameters, and blood pressure also were taken. After 2 hours, of blood was drawn and plasma glucose concentration measured. Diagnosis of diabetes or impaired glucose tolerance was based on 1985 World Health Organization (WHO) cut-off values. Blood glucose results were available in 875 subjects. Seven subjects were found to be diabetic for a prevalence of 0.8%, with the majority (5 subjects) being newly diagnosed. Nineteen were found to have impaired glucose tolerance for a prevalence of 2.2%. There were no sex differences between the two groups. All of the newly diagnosed diabetics were asymptomatic. Multivariate analysis revealed that subjects with a family history of diabetes, higher body mass index, and higher systolic blood pressure had higher blood glucose levels. The prevalence of diabetes in this survey is lower than rates reported in recent surveys in Nigeria that used less stringent criteria and different methodologies. The rate is comparable to that of a Tanzanian study that used WHO criteria. However, the rate of impaired glucose tolerance in this study, first to be reported in Nigeria, is lower than that obtained in the Bantu population.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Akanji A. O. Malnutrition-related diabetes mellitus in young adult diabetic patients attending a Nigerian diabetic clinic. J Trop Med Hyg. 1990 Feb;93(1):35–38. [PubMed] [Google Scholar]
  2. Akinkugbe O. O., Ojo O. A. Arterial pressures in rural and urban populations in Nigeria. Br Med J. 1969 Apr 26;2(5651):222–224. doi: 10.1136/bmj.2.5651.222. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bennett P. H., Rushforth N. B., Miller M., LeCompte P. M. Epidemiologic studies of diabetes in the Pima Indians. Recent Prog Horm Res. 1976;32:333–376. doi: 10.1016/b978-0-12-571132-6.50021-x. [DOI] [PubMed] [Google Scholar]
  4. Brown D. C., Byrne C. D., Clark P. M., Cox B. D., Day N. E., Hales C. N., Shackleton J. R., Wang T. W., Williams D. R. Height and glucose tolerance in adult subjects. Diabetologia. 1991 Jul;34(7):531–533. doi: 10.1007/BF00403292. [DOI] [PubMed] [Google Scholar]
  5. Cooper R. S., Rotimi C. N., Kaufman J. S., Owoaje E. E., Fraser H., Forrester T., Wilks R., Riste L. K., Cruickshank J. K. Prevalence of NIDDM among populations of the African diaspora. Diabetes Care. 1997 Mar;20(3):343–348. doi: 10.2337/diacare.20.3.343. [DOI] [PubMed] [Google Scholar]
  6. Diabetes mellitus. Report of a WHO Study Group. World Health Organ Tech Rep Ser. 1985;727:1–113. [PubMed] [Google Scholar]
  7. Dowse G. K., Zimmet P. Z., King H. Relationship between prevalence of impaired glucose tolerance and NIDDM in a population. Diabetes Care. 1991 Nov;14(11):968–974. doi: 10.2337/diacare.14.11.968. [DOI] [PubMed] [Google Scholar]
  8. Edelstein S. L., Knowler W. C., Bain R. P., Andres R., Barrett-Connor E. L., Dowse G. K., Haffner S. M., Pettitt D. J., Sorkin J. D., Muller D. C. Predictors of progression from impaired glucose tolerance to NIDDM: an analysis of six prospective studies. Diabetes. 1997 Apr;46(4):701–710. doi: 10.2337/diab.46.4.701. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Erasmus R. T., Fakeye T., Olukoga O., Okesina A. B., Ebomoyi E., Adeleye M., Arije A. Prevalence of diabetes mellitus in a Nigerian population. Trans R Soc Trop Med Hyg. 1989 May-Jun;83(3):417–418. doi: 10.1016/0035-9203(89)90524-5. [DOI] [PubMed] [Google Scholar]
  10. Fuller J. H., Shipley M. J., Rose G., Jarrett R. J., Keen H. Coronary-heart-disease risk and impaired glucose tolerance. The Whitehall study. Lancet. 1980 Jun 28;1(8183):1373–1376. doi: 10.1016/s0140-6736(80)92651-3. [DOI] [PubMed] [Google Scholar]
  11. Harris M. I. Epidemiological correlates of NIDDM in Hispanics, whites, and blacks in the U.S. population. Diabetes Care. 1991 Jul;14(7):639–648. doi: 10.2337/diacare.14.7.639. [DOI] [PubMed] [Google Scholar]
  12. Harris M. I., Hadden W. C., Knowler W. C., Bennett P. H. Prevalence of diabetes and impaired glucose tolerance and plasma glucose levels in U.S. population aged 20-74 yr. Diabetes. 1987 Apr;36(4):523–534. doi: 10.2337/diab.36.4.523. [DOI] [PubMed] [Google Scholar]
  13. Jarrett R. J., Keen H., Fuller J. H., McCartney M. Worsening to diabetes in men with impaired glucose tolerance ("borderline diabetes"). Diabetologia. 1979 Jan;16(1):25–30. doi: 10.1007/BF00423146. [DOI] [PubMed] [Google Scholar]
  14. Jarrett R. J., McCartney P., Keen H. The Bedford survey: ten year mortality rates in newly diagnosed diabetics, borderline diabetics and normoglycaemic controls and risk indices for coronary heart disease in borderline diabetics. Diabetologia. 1982 Feb;22(2):79–84. doi: 10.1007/BF00254833. [DOI] [PubMed] [Google Scholar]
  15. KINNEAR T. W. The pattern of diabetes mellitus in a Nigerian teaching hospital. East Afr Med J. 1963 May;40:288–294. [PubMed] [Google Scholar]
  16. Keen H., Jarrett R. J., McCartney P. The ten-year follow-up of the Bedford survey (1962-1972): glucose tolerance and diabetes. Diabetologia. 1982 Feb;22(2):73–78. doi: 10.1007/BF00254832. [DOI] [PubMed] [Google Scholar]
  17. King H., Rewers M. Diabetes in adults is now a Third World problem. The WHO Ad Hoc Diabetes Reporting Group. Bull World Health Organ. 1991;69(6):643–648. [PMC free article] [PubMed] [Google Scholar]
  18. King H., Rewers M. Global estimates for prevalence of diabetes mellitus and impaired glucose tolerance in adults. WHO Ad Hoc Diabetes Reporting Group. Diabetes Care. 1993 Jan;16(1):157–177. doi: 10.2337/diacare.16.1.157. [DOI] [PubMed] [Google Scholar]
  19. Knowler W. C., Pettitt D. J., Saad M. F., Bennett P. H. Diabetes mellitus in the Pima Indians: incidence, risk factors and pathogenesis. Diabetes Metab Rev. 1990 Feb;6(1):1–27. doi: 10.1002/dmr.5610060101. [DOI] [PubMed] [Google Scholar]
  20. McLarty D. G., Swai A. B., Kitange H. M., Masuki G., Mtinangi B. L., Kilima P. M., Makene W. J., Chuwa L. M., Alberti K. G. Prevalence of diabetes and impaired glucose tolerance in rural Tanzania. Lancet. 1989 Apr 22;1(8643):871–875. doi: 10.1016/s0140-6736(89)92866-3. [DOI] [PubMed] [Google Scholar]
  21. O'Dea K. Marked improvement in carbohydrate and lipid metabolism in diabetic Australian aborigines after temporary reversion to traditional lifestyle. Diabetes. 1984 Jun;33(6):596–603. doi: 10.2337/diab.33.6.596. [DOI] [PubMed] [Google Scholar]
  22. O'Sullivan J. B., Mahan C. M. Prospective study of 352 young patients with chemical diabetes. N Engl J Med. 1968 May 9;278(19):1038–1041. doi: 10.1056/NEJM196805092781904. [DOI] [PubMed] [Google Scholar]
  23. Ohwovoriole A. E., Kuti J. A., Kabiawu S. I. Casual blood glucose levels and prevalence of undiscovered diabetes mellitus in Lagos Metropolis Nigerians. Diabetes Res Clin Pract. 1988 Jan 7;4(2):153–158. doi: 10.1016/s0168-8227(88)80010-x. [DOI] [PubMed] [Google Scholar]
  24. Osuntokun B. O., Akinkugbe F. M., Francis T. I., Reddy S., Osuntokun O., Taylor G. O. Diabetes mellitus in Nigerians: a study of 832 patients. West Afr Med J Niger Pract. 1971 Oct;20(5):295–312. [PubMed] [Google Scholar]
  25. Pan X. R., Li G. W., Hu Y. H., Wang J. X., Yang W. Y., An Z. X., Hu Z. X., Lin J., Xiao J. Z., Cao H. B. Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care. 1997 Apr;20(4):537–544. doi: 10.2337/diacare.20.4.537. [DOI] [PubMed] [Google Scholar]
  26. Reid D. D., Brett G. Z., Hamilton P. J., Jarrett R. J., Keen H., Rose G. Cardiorespiratory disease and diabetes among middle-aged male Civil Servants. A study of screening and intervention. Lancet. 1974 Mar 23;1(7856):469–473. doi: 10.1016/s0140-6736(74)92783-4. [DOI] [PubMed] [Google Scholar]
  27. Saad M. F., Knowler W. C., Pettitt D. J., Nelson R. G., Mott D. M., Bennett P. H. The natural history of impaired glucose tolerance in the Pima Indians. N Engl J Med. 1988 Dec 8;319(23):1500–1506. doi: 10.1056/NEJM198812083192302. [DOI] [PubMed] [Google Scholar]
  28. Salmerón J., Ascherio A., Rimm E. B., Colditz G. A., Spiegelman D., Jenkins D. J., Stampfer M. J., Wing A. L., Willett W. C. Dietary fiber, glycemic load, and risk of NIDDM in men. Diabetes Care. 1997 Apr;20(4):545–550. doi: 10.2337/diacare.20.4.545. [DOI] [PubMed] [Google Scholar]
  29. Salmerón J., Manson J. E., Stampfer M. J., Colditz G. A., Wing A. L., Willett W. C. Dietary fiber, glycemic load, and risk of non-insulin-dependent diabetes mellitus in women. JAMA. 1997 Feb 12;277(6):472–477. doi: 10.1001/jama.1997.03540300040031. [DOI] [PubMed] [Google Scholar]
  30. Sayegh H. A., Jarrett R. J. Oral glucose-tolerance tests and the diagnosis of diabetes: results of a prospective study based on the Whitehall survey. Lancet. 1979 Sep 1;2(8140):431–433. doi: 10.1016/s0140-6736(79)91489-2. [DOI] [PubMed] [Google Scholar]
  31. Swai A. B., Kitange H. M., Masuki G., Kilima P. M., Alberti K. G., McLarty D. G. Is diabetes mellitus related to undernutrition in rural Tanzania? BMJ. 1992 Oct 31;305(6861):1057–1062. doi: 10.1136/bmj.305.6861.1057. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Swai A. B., Lutale J. L., McLarty D. G. Prospective study of incidence of juvenile diabetes mellitus over 10 years in Dar es Salaam, Tanzania. BMJ. 1993 Jun 12;306(6892):1570–1572. doi: 10.1136/bmj.306.6892.1570. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Teuscher T., Baillod P., Rosman J. B., Teuscher A. Absence of diabetes in a rural West African population with a high carbohydrate/cassava diet. Lancet. 1987 Apr 4;1(8536):765–768. doi: 10.1016/s0140-6736(87)92797-8. [DOI] [PubMed] [Google Scholar]
  34. Trinder P. Determination of blood glucose using 4-amino phenazone as oxygen acceptor. J Clin Pathol. 1969 Mar;22(2):246–246. doi: 10.1136/jcp.22.2.246-b. [DOI] [PMC free article] [PubMed] [Google Scholar]

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