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. 1986 May;52(2):613–616. doi: 10.1128/iai.52.2.613-616.1986

Evidence for lipid peroxidation in endotoxin-poisoned mice.

D L Peavy, E J Fairchild 2nd
PMCID: PMC261045  PMID: 3516882

Abstract

Ethane has been identified and quantitated in air exhaled by mice following intraperitoneal injection of 20, 40, or 200 mg of Escherichia coli O111:B4 lipopolysaccharide (LPS) per kg. Significant increases in ethane concentration occurred within 1 to 5 h after LPS administration. In addition, increased concentrations of malondialdehyde were found in crude homogenates of livers obtained from mice 16 h after administration of 20 mg of LPS per kg. These results suggest that lipid peroxidation may be an important mechanism responsible for LPS toxicity.

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Selected References

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