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. 1984 Oct;46(1):267–269. doi: 10.1128/iai.46.1.267-269.1984

Unique and common protective epitopes among different serotypes of group A streptococcal M proteins defined with hybridoma antibodies.

J B Dale, E H Beachey
PMCID: PMC261470  PMID: 6207110

Abstract

A set of four monoclonal antibodies was produced against a highly purified pepsin extract of type 5 streptococcal M protein. Three of the four antibodies cross-reacted with purified M proteins from heterologous serotypes and opsonized the respective heterologous organisms. Our studies suggest that monoclonal antibodies may be useful in identifying subpeptides of various M proteins containing common, protective epitopes that are capable of evoking antibodies that would protect against several different potentially "rheumatogenic" serotypes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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