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. 1990 Jan;82(1):41–48.

Serial evaluation of iron stores in pregnant Nigerians with hemoglobin SS or SC.

O O Abudu 1, K Macaulay 1, O A Oluboyede 1
PMCID: PMC2625931  PMID: 2304096

Abstract

Iron status of nonpregnant and pregnant Nigerian patients with hemoglobin SS or SC were assessed using serial hematological parameters, measured by Coulter counter, and serial serum ferritin concentrations measured by radioimmunoassays. The median value of 393 micrograms/L (range, 175 to 900 micrograms/L) for serum ferritin in nonpregnant patients with Hb SS and SC was significantly higher than that found in nonpregnant patients with Hb AA (median, 89.8 micrograms/L; range, 13 to 250 micrograms/L). Apart from packed cell volume values, there were no other significant differences between patients with Hb SS or SC and Hb AA in the other parameters assessed: mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration. In both the normal pregnant patients (Hb AA) and pregnant patients with Hb SS and SC the serum ferritin values decreased as pregnancy advanced to 28 weeks and rose gradually thereafter. At similar stages of gestation serum ferritin values were significantly higher in patients with Hb SS or SC than in those with Hb AA. Pregnancy seems to have induced a significant rise in mean corpuscular volume and mean corpuscular hemoglobin values in the patients with Hb SS or SC, especially in the third trimester, than in patients with Hb AA. The pattern of change in mean corpuscular hemoglobin concentration values was similar in both groups of patients. From the data obtained, it seems the iron status in the patients with Hb SS or SC was good, and pregnancy did not push the patients into an iron deficiency state. The use of prophylactic iron supplementation in pregnant patients with Hb SS or SC appears unjustified.

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Selected References

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  1. Addae S., Konotey-Ahulu F. I. Lack of diurnal variations in sodium, potassium and osmolal excretion in the sickle cell patient. Afr J Med Sci. 1971 Oct;2(4):349–359. [PubMed] [Google Scholar]
  2. Anderson M. F. The iron status of pregnant women with hemoglobinopathies. Am J Obstet Gynecol. 1972 Aug 1;113(7):895–900. doi: 10.1016/0002-9378(72)90653-9. [DOI] [PubMed] [Google Scholar]
  3. Fleming A. F. Iron status of anaemic pregnant Nigerians. J Obstet Gynaecol Br Commonw. 1969 Nov;76(11):1013–1017. doi: 10.1111/j.1471-0528.1969.tb09469.x. [DOI] [PubMed] [Google Scholar]
  4. Hendrickse J. P., Watson-Williams E. J., Luzzatto L., Ajabor L. N. Pregnancy in homozygous sickle-cell anaemia. J Obstet Gynaecol Br Commonw. 1972 May;79(5):396–409. doi: 10.1111/j.1471-0528.1972.tb14177.x. [DOI] [PubMed] [Google Scholar]
  5. Jacobs A., Worwood M. Ferritin in serum. Clinical and biochemical implications. N Engl J Med. 1975 May 1;292(18):951–956. doi: 10.1056/NEJM197505012921805. [DOI] [PubMed] [Google Scholar]
  6. Oluboyede O. A. Iron studies in pregnant and non-pregnant women with haemoglobin SS or SC disease. Br J Obstet Gynaecol. 1980 Nov;87(11):989–996. doi: 10.1111/j.1471-0528.1980.tb04463.x. [DOI] [PubMed] [Google Scholar]
  7. Oluboyede O. A., Usanga E. A., Lukanmbi F. A., Ajayi O. A. Evaluation of serum ferritin levels and other hematological parameters in a Nigerian population. J Natl Med Assoc. 1983 Sep;75(9):885–889. [PMC free article] [PubMed] [Google Scholar]
  8. Peterson C. M., Graziano J. H., de Ciutiis A., Grady R. W., Cerami A., Worwood M., Jacobs A. Iron metabolism, sickle cell disease, and response to cyanate. Blood. 1975 Oct;46(4):583–590. [PubMed] [Google Scholar]
  9. Puolakka J., Jänne O., Pakarinen A., Järvinen P. A., Vihko R. Serum ferritin as a measure of iron stores during and after normal pregnancy with and without iron supplements. Acta Obstet Gynecol Scand Suppl. 1980;95:43–51. doi: 10.3109/00016348009156379. [DOI] [PubMed] [Google Scholar]
  10. Roopnarinesingh S. Iron stores in pregnant patients with anaemia and haemoglobin S. Br J Obstet Gynaecol. 1976 May;83(5):375–377. doi: 10.1111/j.1471-0528.1976.tb00845.x. [DOI] [PubMed] [Google Scholar]
  11. Taylor D. J., Lind T. Haematological changes during normal pregnancy: iron induced macrocytosis. Br J Obstet Gynaecol. 1976 Oct;83(10):760–767. doi: 10.1111/j.1471-0528.1976.tb00740.x. [DOI] [PubMed] [Google Scholar]
  12. Taylor D. J., Mallen C., McDougall N., Lind T. Effect of iron supplementation on serum ferritin levels during and after pregnancy. Br J Obstet Gynaecol. 1982 Dec;89(12):1011–1017. doi: 10.1111/j.1471-0528.1982.tb04656.x. [DOI] [PubMed] [Google Scholar]
  13. Van Eijk H. G., Kroos M. J., Hoogendoorn G. A., Wallenburg H. C. Serum ferritin and iron stores during pregnancy. Clin Chim Acta. 1978 Feb 1;83(1-2):81–91. doi: 10.1016/0009-8981(78)90210-3. [DOI] [PubMed] [Google Scholar]

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