Skip to main content
PMC home page
Infection and Immunity logoLink to Infection and Immunity
. 1984 Jul;45(1):278–280. doi: 10.1128/iai.45.1.278-280.1984

Species differences in Kupffer cells and endotoxin sensitivity.

R S McCuskey, P A McCuskey, R Urbaschek, B Urbaschek
PMCID: PMC263314  PMID: 6376358

Abstract

The relative species sensitivity to Escherichia coli O111:B4 endotoxin was found to be guinea pig greater than hamster greater than mouse greater than rat. The 50% lethal dose of this endotoxin correlated with both the rate at which single latex particles were phagocytosed by individual Kupffer cells and the number of Kupffer cells in hepatic lobules that phagocytosed latex. The results suggests that the intrahepatic density and the level of activation of Kupffer cells participate in determining endotoxin sensitivity.

Full text

PDF
280

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Berry L. J. Bacterial toxins. CRC Crit Rev Toxicol. 1977 Nov;5(3):239–318. doi: 10.3109/10408447709082601. [DOI] [PubMed] [Google Scholar]
  2. Bhatnagar R., Schirmer R., Ernst M., Decker K. Superoxide release by zymosan-stimulated rat Kupffer cells in vitro. Eur J Biochem. 1981 Sep;119(1):171–175. doi: 10.1111/j.1432-1033.1981.tb05590.x. [DOI] [PubMed] [Google Scholar]
  3. Maier R. V., Ulevitch R. J. The response of isolated rabbit hepatic macrophages (H-M macrophage) to lipopolysaccharide (LPS). Circ Shock. 1981;8(2):165–181. [PubMed] [Google Scholar]
  4. Mathison J. C., Ulevitch R. J. The clearance, tissue distribution, and cellular localization of intravenously injected lipopolysaccharide in rabbits. J Immunol. 1979 Nov;123(5):2133–2143. [PubMed] [Google Scholar]
  5. McCuskey R. S. In vivo microscopy of internal organs. Prog Clin Biol Res. 1981;59B:79–87. [PubMed] [Google Scholar]
  6. McCuskey R. S., Reilly F. D., McCuskey P. A., Dimlich R. V. In vivo microscopy of the hepatic microvascular system. Bibl Anat. 1979;(18):73–76. [PubMed] [Google Scholar]
  7. McCuskey R. S., Urbaschek R., McCuskey P. A., Urbaschek B. In vivo microscopic observations of the responses of Kupffer cells and the hepatic microcirculation to Mycobacterium bovis BCG alone and in combination with endotoxin. Infect Immun. 1983 Oct;42(1):362–367. doi: 10.1128/iai.42.1.362-367.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. McCuskey R. S., Urbaschek R., McCuskey P. A., Urbaschek B. In vivo microscopic studies of the responses of the liver to endotoxin. Klin Wochenschr. 1982 Jul 15;60(14):749–751. doi: 10.1007/BF01716570. [DOI] [PubMed] [Google Scholar]
  9. Ruiter D. J., van der Meulen J., Brouwer A., Hummel M. J., Mauw B. J., van der Ploeg J. C., Wisse E. Uptake by liver cells of endotoxin following its intravenous injection. Lab Invest. 1981 Jul;45(1):38–45. [PubMed] [Google Scholar]
  10. Urbaschek B., Urbaschek R. The inflammatory response to endotoxins. Bibl Anat. 1979;(17):74–104. [PubMed] [Google Scholar]
  11. Urbaschek R., Urbaschek B. Aspects of beneficial endotoxin-mediated effects. Klin Wochenschr. 1982 Jul 15;60(14):746–748. doi: 10.1007/BF01716569. [DOI] [PubMed] [Google Scholar]
  12. ZWEIFACH B. W. Aspects of comparative physiology of laboratory animals relative to the problem of experimental shock. Fed Proc. 1961 Jul;20(Suppl 9):18–29. [PubMed] [Google Scholar]
  13. Zwilling B. S., Koegel M., Campolito L. B. Lack of lipopolysaccharide response of inbred strains of Syrian hamsters. Dev Comp Immunol. 1982 Spring;6(2):349–358. doi: 10.1016/s0145-305x(82)80018-9. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES