Abstract
There are racial differences in prostate cancer outcomes. One variable influencing end results is treatment for cure: either radical prostatectomy (RP) or radiation therapy (RT). The purpose of this report is to determine changes in diagnosis rates of localized prostate cancer between the years before prostate-specific antigen (PSA) use (1973-1988) and the years after PSA use (1989-1996), to evaluate differences in RP and RT rates between the pre-PSA and post-PSA eras, to assess differences in RP and RT rates between African Americans and whites between these intervals. The Surveillance, Epidemiology, and End Results (SEER) data were used and evaluated. Both African Americans and whites had statistically increased rates of localized prostate cancer diagnosed (70.4 and 49.0 in 1973 through 1988 and 123.1 and 84.9 in 1989 through 1996, respectively [p < 0.05]). The differences between the pre-PSA and post-PSA eras for African Americans and whites for RP (3.6 vs. 44.3 and 5.0 vs. 44.9, respectively) and RT (23.6 vs. 61.6 and 17.0 vs. 38.1, respectively) were all significant (p < 0.05). Both African Americans and whites had increased rates of RP from 3.6 and 5.0 to 44.3 and 44.9, respectively, and RT from 23.6 and 17.0 to 61.6 and 38.1 during the pre- and post-PSA years.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Boring C. C., Squires T. S., Health C. W., Jr Cancer statistics for African Americans. CA Cancer J Clin. 1992 Jan-Feb;42(1):7–17. doi: 10.3322/canjclin.42.1.7. [DOI] [PubMed] [Google Scholar]
- Brawer M. K. Prostate cancer: epidemiology and screening. Prostate Cancer Prostatic Dis. 1999 Jan;2(S1):2–6. doi: 10.1038/sj.pcan.4500270. [DOI] [PubMed] [Google Scholar]
- Harlan L., Brawley O., Pommerenke F., Wali P., Kramer B. Geographic, age, and racial variation in the treatment of local/regional carcinoma of the prostate. J Clin Oncol. 1995 Jan;13(1):93–100. doi: 10.1200/JCO.1995.13.1.93. [DOI] [PubMed] [Google Scholar]
- Imperato P. J., Nenner R. P., Will T. O. Radical prostatectomy: lower rates among African-American men. J Natl Med Assoc. 1996 Sep;88(9):589–594. [PMC free article] [PubMed] [Google Scholar]
- Klabunde C. N., Potosky A. L., Harlan L. C., Kramer B. S. Trends and black/white differences in treatment for nonmetastatic prostate cancer. Med Care. 1998 Sep;36(9):1337–1348. doi: 10.1097/00005650-199809000-00006. [DOI] [PubMed] [Google Scholar]
- Mettlin C. J., Murphy G. P., Cunningham M. P., Menck H. R. The National Cancer Data Base report on race, age, and region variations in prostate cancer treatment. Cancer. 1997 Oct 1;80(7):1261–1266. [PubMed] [Google Scholar]
- Mettlin C. J., Murphy G. P., McGinnis L. S., Menck H. R. The National Cancer Data Base report on prostate cancer. American College of Surgeons Commission on Cancer and the American Cancer Society. Cancer. 1995 Sep 15;76(6):1104–1112. doi: 10.1002/1097-0142(19950915)76:6<1104::aid-cncr2820760627>3.0.co;2-d. [DOI] [PubMed] [Google Scholar]
- Roach M., 3rd, Lu J., Pilepich M. V., Asbell S. O., Mohiuddin M., Terry R., Grignon D. Long-term survival after radiotherapy alone: radiation therapy oncology group prostate cancer trials. J Urol. 1999 Mar;161(3):864–868. doi: 10.1016/s0022-5347(01)61793-2. [DOI] [PubMed] [Google Scholar]
- Schapira M. M., McAuliffe T. L., Nattinger A. B. Treatment of localized prostate cancer in African-American compared with Caucasian men. Less use of aggressive therapy for comparable disease. Med Care. 1995 Nov;33(11):1079–1088. doi: 10.1097/00005650-199511000-00002. [DOI] [PubMed] [Google Scholar]