Skip to main content
PMC home page
Infection and Immunity logoLink to Infection and Immunity
. 1983 Dec;42(3):1049–1054. doi: 10.1128/iai.42.3.1049-1054.1983

Induction of interleukin 1 secretion by adjuvant-active peptidoglycans.

F Vacheron, M Guenounou, C Nauciel
PMCID: PMC264406  PMID: 6605929

Abstract

The ability of differently structured, purified peptidoglycans (PG) to induce interleukin 1 (IL1) secretion was compared. PG from Bacillus megaterium and Staphylococcus aureus stimulated the production of IL1 by mouse peritoneal macrophages and human adherent mononuclear cells, whereas PG from Micrococcus lysodeikticus and Corynebacterium poinsettiae were inactive. There was a correlation between the ability of PG to induce IL1 secretion and previously demonstrated immunoenhancing activities (adjuvant effect, increase of resistance to tumor growth) of PG. PG solubilization by lysozyme decreased but did not abolish the PG effect on IL1 secretion. Active PG induced IL1 production in nude mice and in the C3H/HeJ strain (which is unresponsive to lipopolysaccharides).

Full text

PDF
1053

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Böyum A. Isolation of leucocytes from human blood. Further observations. Methylcellulose, dextran, and ficoll as erythrocyteaggregating agents. Scand J Clin Lab Invest Suppl. 1968;97:31–50. [PubMed] [Google Scholar]
  2. Chedid L., Audibert F., Johnson A. G. Biological activities of muramyl dipeptide, a synthetic glycopeptide analogous to bacterial immunoregulating agents. Prog Allergy. 1978;25:63–105. [PubMed] [Google Scholar]
  3. Damais C., Bona C., Chedid L., Fleck J., Nauciel C., Martin J. P. Mitogenic effect of bacterial peptidoglycans possessing adjuvant activity. J Immunol. 1975 Jul;115(1):268–271. [PubMed] [Google Scholar]
  4. Dziarski R., Dziarski A. Mitogenic activity of staphylococcal peptidoglycan. Infect Immun. 1979 Mar;23(3):706–710. doi: 10.1128/iai.23.3.706-710.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Ellouz F., Adam A., Ciorbaru R., Lederer E. Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives. Biochem Biophys Res Commun. 1974 Aug 19;59(4):1317–1325. doi: 10.1016/0006-291x(74)90458-6. [DOI] [PubMed] [Google Scholar]
  6. Gery I., Waksman B. H. Potentiation of the T-lymphocyte response to mitogens. II. The cellular source of potentiating mediator(s). J Exp Med. 1972 Jul 1;136(1):143–155. doi: 10.1084/jem.136.1.143. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Gillis S., Union N. A., Baker P. E., Smith K. A. The in vitro generation and sustained culture of nude mouse cytolytic T-lymphocytes. J Exp Med. 1979 Jun 1;149(6):1460–1476. doi: 10.1084/jem.149.6.1460. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Goguel A. F., Lespinats G., Nauciel C. Peptidoglycans extracted from gram-positive bacteria: expression of antitumor activity according to peptide structure and route of injection. J Natl Cancer Inst. 1982 Apr;68(4):657–663. [PubMed] [Google Scholar]
  9. Guenounou M., Goguel A. F., Nauciel C. Study of adjuvant and mitogenic activities of bacterial peptidoglycans with different structures. Ann Immunol (Paris) 1982 Jul-Aug;133D(1):3–13. [PubMed] [Google Scholar]
  10. Heymer B., Bültmann B., Schachenmayr W., Spanel R., Haferkamp O., Schmidt W. C. Migration inhibition of rat peritoneal cells induced by streptococcal mucopeptides. Characteristics of the reaction and properties of the mucopeptide preparations. J Immunol. 1973 Dec;111(6):1743–1754. [PubMed] [Google Scholar]
  11. Hoffmann M. K., Koenig S., Mittler R. S., Oettgen H. F., Ralph P., Galanos C., Hammerling U. Macrophage factor controlling differentiation of B cells. J Immunol. 1979 Feb;122(2):497–502. [PubMed] [Google Scholar]
  12. Mizel S. B. Interleukin 1 and T cell activation. Immunol Rev. 1982;63:51–72. doi: 10.1111/j.1600-065x.1982.tb00411.x. [DOI] [PubMed] [Google Scholar]
  13. Nauciel C., Fleck J., Martin J. P., Mock M., Nguyen-Huy H. Adjuvant activity of bacterial peptidoglycans on the production of delayed hypersensitivity and on antibody response. Eur J Immunol. 1974 May;4(5):352–356. doi: 10.1002/eji.1830040509. [DOI] [PubMed] [Google Scholar]
  14. Nauciel C., Fleck J., Mock M., Martin J. P. Activité adjuvante de fractions monomériques de peptidoglycanes bactéiens dans l'hypersensililité de type retardé. C R Acad Sci Hebd Seances Acad Sci D. 1974 Dec 17;277(24):2841–2844. [PubMed] [Google Scholar]
  15. Nauciel C., Goguel A. F. Inhibition of tumor growth by the peptidoglycan from Bacillus megaterium. J Natl Cancer Inst. 1977 Dec;59(6):1723–1726. doi: 10.1093/jnci/59.6.1723. [DOI] [PubMed] [Google Scholar]
  16. Oppenheim J. J., Stadler B. M., Siraganian R. P., Mage M., Mathieson B. Lymphokines: their role in lymphocyte responses. Properties of interleukin 1. Fed Proc. 1982 Feb;41(2):257–262. [PubMed] [Google Scholar]
  17. Oppenheim J. J., Togawa A., Chedid L., Mizel S. Components of mycobacteria and muramyl dipeptide with adjuvant activity induce lymphocyte activating factor. Cell Immunol. 1980 Mar 1;50(1):71–81. doi: 10.1016/0008-8749(80)90007-6. [DOI] [PubMed] [Google Scholar]
  18. Saiki I., Kamisango K., Tanio Y., Okumura H., Yamamura Y., Azuma I. Adjuvant activity of purified peptidoglycan of Listeria monocytogenes in mice and guinea pigs. Infect Immun. 1982 Oct;38(1):58–65. doi: 10.1128/iai.38.1.58-65.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Schleifer K. H., Kandler O. Peptidoglycan types of bacterial cell walls and their taxonomic implications. Bacteriol Rev. 1972 Dec;36(4):407–477. doi: 10.1128/br.36.4.407-477.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Staruch M. J., Wood D. D. The adjuvanticity of interleukin 1 in vivo. J Immunol. 1983 May;130(5):2191–2194. [PubMed] [Google Scholar]
  21. Takada H., Tsujimoto M., Kato K., Kotani S., Kusumoto S., Inage M., Shiba T., Yano I., Kawata S., Yokogawa K. Macrophage activation by bacterial cell walls and related synthetic compounds. Infect Immun. 1979 Jul;25(1):48–53. doi: 10.1128/iai.25.1.48-53.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Tenu J. P., Lederer E., Petit J. F. Stimulation of thymocyte mitogenic protein secretion and of cytostatic activity of mouse peritoneal macrophages by trehalose dimycolate and muramyldipeptide. Eur J Immunol. 1980 Aug;10(8):647–653. doi: 10.1002/eji.1830100813. [DOI] [PubMed] [Google Scholar]
  23. Yam L. T., Li C. Y., Crosby W. H. Cytochemical identification of monocytes and granulocytes. Am J Clin Pathol. 1971 Mar;55(3):283–290. doi: 10.1093/ajcp/55.3.283. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES