Skip to main content
PMC home page
Infection and Immunity logoLink to Infection and Immunity
. 1983 Oct;42(1):122–125. doi: 10.1128/iai.42.1.122-125.1983

Differential effects of gamma interferon on expression of HLA class II molecules controlled by the DR and DC loci.

F Ameglio, M R Capobianchi, A Dolei, R Tosi
PMCID: PMC264532  PMID: 6413409

Abstract

Interferon-gamma affected the expression of the products of the immunoassociated antigen complex by a differential modulation of DR- and DC-locus-controlled molecules. In melanoma M14 cells treated with interferon-gamma, levels of DR molecules were increased two- to threefold, whereas levels of DC molecules were increased six- to sevenfold. Similar effects were induced on the two allelic products of each locus.

Full text

PDF
125

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blalock J. E., Georgiades J. A., Langford M. P., Johnson H. M. Purified human immune interferon has more potent anticellular activity than fibroblast or leukocyte interferon. Cell Immunol. 1980 Feb;49(2):390–394. doi: 10.1016/0008-8749(80)90041-6. [DOI] [PubMed] [Google Scholar]
  2. Bono M. R., Strominger J. L. Direct evidence of homology between human DC-1 antigen and murine I-A molecules. Nature. 1982 Oct 28;299(5886):836–840. doi: 10.1038/299836a0. [DOI] [PubMed] [Google Scholar]
  3. Corte G., Moretta A., Cosulich M. E., Ramarli D., Bargellesi A. A monoclonal anti-DC1 antibody selectivity inhibits the generation of effector T cells mediating specific cytolytic activity. J Exp Med. 1982 Nov 1;156(5):1539–1544. doi: 10.1084/jem.156.5.1539. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. De Ley M., Van Damme J., Billiau A., De Somer P. The preparation of antibodies directed against human immune interferon. J Virol Methods. 1981 Oct;3(3):149–153. doi: 10.1016/0166-0934(81)90049-5. [DOI] [PubMed] [Google Scholar]
  5. Dolei A., Capobianchi M. R., Ameglio F. Human interferon-gamma enhances the expression of class I and class II major histocompatibility complex products in neoplastic cells more effectively than interferon-alpha and interferon-beta. Infect Immun. 1983 Apr;40(1):172–176. doi: 10.1128/iai.40.1.172-176.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Fellous M., Kamoun M., Gresser I., Bono R. Enhanced expression of HLA antigens and beta 2-microglobulin on interferon-treated human lymphoid cells. Eur J Immunol. 1979 Jun;9(6):446–449. doi: 10.1002/eji.1830090606. [DOI] [PubMed] [Google Scholar]
  7. Fleischmann W. R., Jr Potentiation of the direct anticellular activity of mouse interferons: mutual synergism and interferon concentration dependence. Cancer Res. 1982 Mar;42(3):869–875. [PubMed] [Google Scholar]
  8. Heron I., Hokland M., Berg K. Enhanced expression of beta2-microglobulin and HLA antigens on human lymphoid cells by interferon. Proc Natl Acad Sci U S A. 1978 Dec;75(12):6215–6219. doi: 10.1073/pnas.75.12.6215. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hirschberg H., Braathen L. R., Thorsby E. Antigen presentation by vascular endothelial cells and epidermal Langerhans cells: the role of HLA-DR. Immunol Rev. 1982;66:57–77. doi: 10.1111/j.1600-065x.1982.tb00434.x. [DOI] [PubMed] [Google Scholar]
  10. Rossi G. B., Dolei A., Capobianchi M. R., Peschle C., Affabris E. Interactions of interferon with in vitro model systems involved in hematopoietic cell differentiation. Ann N Y Acad Sci. 1980;350:279–293. doi: 10.1111/j.1749-6632.1980.tb20628.x. [DOI] [PubMed] [Google Scholar]
  11. Rossi G. B., Dolei A., Cioè L., Peschle C. Effect of interferon on erythropoietic differentiation. Tex Rep Biol Med. 1981;41:381–387. [PubMed] [Google Scholar]
  12. Rubin B. Y., Gupta S. L. Differential efficacies of human type I and type II interferons as antiviral and antiproliferative agents. Proc Natl Acad Sci U S A. 1980 Oct;77(10):5928–5932. doi: 10.1073/pnas.77.10.5928. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Sonnenfeld G., Meruelo D., McDevitt H. O., Merigan T. C. Effect of type I and type II interferons on murine thymocyte surface antigen expression: induction or selection? Cell Immunol. 1981 Jan 15;57(2):427–439. doi: 10.1016/0008-8749(81)90101-5. [DOI] [PubMed] [Google Scholar]
  14. Tanigaki N., Tosi R. Assessment of the specificity of human Ia alloantisera and alloantigens by the use of radioiodinated human Ia antigens. Tissue Antigens. 1982 Jul;20(1):1–21. doi: 10.1111/j.1399-0039.1982.tb00324.x. [DOI] [PubMed] [Google Scholar]
  15. Tanigaki N., Tosi R., Centis D., Ferrara G. B., Pressman D. Further characterization of two "DR supertypic" specificities. Additional evidence that they reside on molecules different from those carrying HLA-DR locus specificities. Hum Immunol. 1981 Oct;3(2):93–108. doi: 10.1016/0198-8859(81)90047-1. [DOI] [PubMed] [Google Scholar]
  16. Tanigaki N., Tosi R., Duquesnoy R. J., Ferrara G. B. Three Ia species with different structures and alloantigenic determinants in an HLA-homozygous cell line. J Exp Med. 1983 Jan 1;157(1):231–247. doi: 10.1084/jem.157.1.231. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Tanigaki N., Tosi R., Koyama K., Pressman D. Purification and separation of subsets of human Ia molecules by papain digestion. Immunology. 1980 Apr;39(4):615–622. [PMC free article] [PubMed] [Google Scholar]
  18. Tanigaki N., Tosi R. The genetic control of human Ia alloantigens: a three-loci model derived from the immunochemical analysis of 'supertypic' specificities. Immunol Rev. 1982;66:5–37. doi: 10.1111/j.1600-065x.1982.tb00432.x. [DOI] [PubMed] [Google Scholar]
  19. Tosi R., Tanigaki N., Centis D., Ferrara G. B., Pressman D. Immunological dissection of human Ia molecules. J Exp Med. 1978 Dec 1;148(6):1592–1611. doi: 10.1084/jem.148.6.1592. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Tosi R., Tanigaki N., Centis D., Rossi P. L., Alfano G., Ferrara G. B., Pressman D. HLA-DR typing by radioimmunoassay. Transplantation. 1980 Apr;29(4):302–305. doi: 10.1097/00007890-198004000-00008. [DOI] [PubMed] [Google Scholar]
  21. Wallach D., Fellous M., Revel M. Preferential effect of gamma interferon on the synthesis of HLA antigens and their mRNAs in human cells. Nature. 1982 Oct 28;299(5886):833–836. doi: 10.1038/299833a0. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES