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. 1983 May;40(2):795–805. doi: 10.1128/iai.40.2.795-805.1983

Rapid induction of hypothyroidism by an avian leukosis virus.

J K Carter, R E Smith
PMCID: PMC264924  PMID: 6302005

Abstract

Infection of 10-day chicken embryos with an avian leukosis virus, RAV-7, resulted in hypothyroidism within 3 weeks posthatching. Histological examination of the thyroids from infected chickens showed an extensive infiltration of lymphoblastoid cells by 7 days posthatching. Areas resembling germinal centers were present in the thyroids of infected chickens by 3 weeks posthatching. Examination of circulating thyroid and pancreas hormones showed a significant reduction in T3 and T4 levels and a trend toward higher insulin levels after 16 days posthatching. T4 supplementation of RAV-7-infected chickens alleviated some aspects of the disease syndrome but did not abrogate all symptoms. Marked involution of both bursa and thymus glands was noted. RAV-7 had an RNA genome of 8.2 kilobases and a polypeptide composition characteristic of an avian leukosis virus. The hypothyroidism followed a dose response to RAV-7 infection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BALUDA M. A., JAMIESON P. P. In vivo infectivity studies with avian mveloblastosis virus. Virology. 1961 May;14:33–45. doi: 10.1016/0042-6822(61)90129-5. [DOI] [PubMed] [Google Scholar]
  2. BEARD J. W. VIRAL TUMORS OF CHICKENS WITH PARTICULAR REFERENCE TO THE LEUKOSIS COMPLEX. Ann N Y Acad Sci. 1963 Nov 4;108:1057–1085. doi: 10.1111/j.1749-6632.1963.tb13436.x. [DOI] [PubMed] [Google Scholar]
  3. Banes A. J., Smith R. E. Biological characterization of avian osteopetrosis. Infect Immun. 1977 Jun;16(3):876–884. doi: 10.1128/iai.16.3.876-884.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bannister D. W., Evans A. J., Whitehead C. C. Evidence for a lesion in carbohydrate metabolism in fatty liver and kidney syndrome in chicks. Res Vet Sci. 1975 Mar;18(2):149–156. [PubMed] [Google Scholar]
  5. Butler E. J. Lipid metabolism in the fowl under normal and abnormal circumstances. Proc Nutr Soc. 1975 May;34(1):29–34. doi: 10.1079/pns19750007. [DOI] [PubMed] [Google Scholar]
  6. Carter J. K., Ow C. L., Smith R. E. Rous-associated virus type 7 induces a syndrome in chickens characterized by stunting and obesity. Infect Immun. 1983 Jan;39(1):410–422. doi: 10.1128/iai.39.1.410-422.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Carter J. K., Proctor S. J., Smith R. E. Induction of angiosarcomas by ring-necked pheasant virus. Infect Immun. 1983 Apr;40(1):310–319. doi: 10.1128/iai.40.1.310-319.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Cole R. K. Hereditary hypothyroidism in the domestic fowl. Genetics. 1966 Jun;53(6):1021–1033. doi: 10.1093/genetics/53.6.1021. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Cole R. K., Kite J. H., Jr, Witebsky E. Hereditary autoimmune thyroiditis in the fowl. Science. 1968 Jun 21;160(3834):1357–1358. doi: 10.1126/science.160.3834.1357. [DOI] [PubMed] [Google Scholar]
  10. Correze C., Berriche S., Tamayo L., Nunez J. Effect of thyroid hormones and cyclic AMP on some lipogenic enzymes of the fat cell. Eur J Biochem. 1982 Feb;122(2):387–392. doi: 10.1111/j.1432-1033.1982.tb05893.x. [DOI] [PubMed] [Google Scholar]
  11. Duff R. G., Vogt P. K. Characteristics of two new avian tumor virus subgroups. Virology. 1969 Sep;39(1):18–30. doi: 10.1016/0042-6822(69)90344-4. [DOI] [PubMed] [Google Scholar]
  12. Graf T., Beug H. Avian leukemia viruses: interaction with their target cells in vivo and in vitro. Biochim Biophys Acta. 1978 Nov 17;516(3):269–299. doi: 10.1016/0304-419x(78)90011-2. [DOI] [PubMed] [Google Scholar]
  13. Grossberg S. E., O'Leary W. M. Hyperlipaemia following viral infection in the chicken embryo: a new syndrome. Nature. 1965 Dec 4;208(5014):954–956. doi: 10.1038/208954a0. [DOI] [PubMed] [Google Scholar]
  14. Hamilton P. B., Garlich J. D. Aflatoxin as a possible cause of fatty liver syndrome in laying hens. Poult Sci. 1971 May;50(3):800–804. doi: 10.3382/ps.0500800. [DOI] [PubMed] [Google Scholar]
  15. Husbands D. R., Laursen-Jones A. P. Fatty liver and kidney syndrome. Vet Rec. 1969 Mar 1;84(9):232–233. doi: 10.1136/vr.84.9.232-a. [DOI] [PubMed] [Google Scholar]
  16. Kite J. H., Jr, Wick G., Twarog B., Witebsky E. Spontaneous thyroiditis in an obese strain of chickens. II. Investigations on the development of the disease. J Immunol. 1969 Dec;103(6):1331–1341. [PubMed] [Google Scholar]
  17. Kotani T., Komuro K., Yoshiki T., Itoh T., Aizawa M. Spontaneous autoimmune thyroiditis in the rat accelerated by thymectomy and low doses of irradiation: mechanisms implicated in the pathogenesis. Clin Exp Immunol. 1981 Aug;45(2):329–337. [PMC free article] [PubMed] [Google Scholar]
  18. MIKAMI S. I., ONO K. Glucagon deficiency induced by extirpation of alpha islets of the fowl pancreas. Endocrinology. 1962 Sep;71:464–473. doi: 10.1210/endo-71-3-464. [DOI] [PubMed] [Google Scholar]
  19. Madsen S. N., Sonne O. Increase of glucagon receptors in hyperthyroidism. Nature. 1976 Aug 26;262(5571):793–795. doi: 10.1038/262793a0. [DOI] [PubMed] [Google Scholar]
  20. Paterson R. W., Smith R. E. Characterization of anemia induced by avian osteopetrosis virus. Infect Immun. 1978 Dec;22(3):891–900. doi: 10.1128/iai.22.3.891-900.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Price J. A., Smith R. E. Influence of bursectomy on bone growth and anemia induced by avian osteopetrosis viruses. Cancer Res. 1981 Mar;41(3):752–759. [PubMed] [Google Scholar]
  22. Purchase H. G., Okazaki W., Vogt P. K., Hanafusa H., Burmester B. R., Crittenden L. B. Oncogenicity of avian leukosis viruses of different subgroups and of mutants of sarcoma viruses. Infect Immun. 1977 Feb;15(2):423–428. doi: 10.1128/iai.15.2.423-428.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Raziel A., Rosenzweig B., Botvinic V., Beigel I., Landau B., Blum I. The influence of thyroid function on serum lipid profile. Atherosclerosis. 1982 Feb;41(2-3):321–326. doi: 10.1016/0021-9150(82)90196-4. [DOI] [PubMed] [Google Scholar]
  24. Rup B. J., Hoelzer J. D., Bose H. R., Jr Helper viruses associated with avian acute leukemia viruses inhibit the cellular immune response. Virology. 1982 Jan 15;116(1):61–71. doi: 10.1016/0042-6822(82)90403-2. [DOI] [PubMed] [Google Scholar]
  25. Sanger V. L., Fredrickson T. N., Morrill C. C., Burmester B. R. Pathogenesis of osteopetrosis in chickens. Am J Vet Res. 1966 Nov;27(121):1735–1744. [PubMed] [Google Scholar]
  26. Severson D. L., Fletcher T. Effect of thyroid hormones on acid cholesterol ester hydrolase activity in rat liver, heart and epididymal fat pads. Biochim Biophys Acta. 1981 Jul;675(2):256–264. doi: 10.1016/0304-4165(81)90235-x. [DOI] [PubMed] [Google Scholar]
  27. Singh A., Reineke E. P., Ringer R. K. Influence of thyroid status of the chick on growth and metabolism, with observations on several parameters of thyroid function. Poult Sci. 1968 Jan;47(1):212–219. doi: 10.3382/ps.0470212. [DOI] [PubMed] [Google Scholar]
  28. Smith R. E., Morgan J. H. Identification of plaque isolates of an avian retrovirus causing rapid and slow onset osteopetrosis. Virology. 1982 Jun;119(2):488–499. doi: 10.1016/0042-6822(82)90107-6. [DOI] [PubMed] [Google Scholar]
  29. Smith R. E., Van Eldik L. J. Characterization of the immunosuppression accompanying virus-induced avian osteopetrosis. Infect Immun. 1978 Nov;22(2):452–461. doi: 10.1128/iai.22.2.452-461.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. VAN TIENHOVEN A., COLE R. K. Endocrine disturbances in obese chickens. Anat Rec. 1962 Feb;142:111–121. doi: 10.1002/ar.1091420203. [DOI] [PubMed] [Google Scholar]
  31. Wick G., Boyd R., Hala K., de Carvalho L., Kofler R., Müller P. U., Cole R. K. The obese strain (OS) of chickens with spontaneous autoimmune thyroiditis: review of recent data. Curr Top Microbiol Immunol. 1981;91:109–128. doi: 10.1007/978-3-642-68058-8_5. [DOI] [PubMed] [Google Scholar]
  32. Wick G., Boyd R., Hála K., Thunold S., Kofler H. Pathogenesis of spontaneous autoimmune thyroiditis in Obese strain (OS) chickens. Clin Exp Immunol. 1982 Jan;47(1):1–18. [PMC free article] [PubMed] [Google Scholar]
  33. Witebsky E. The clinical pathology of autoimmunization. Ward Burdick award address. Am J Clin Pathol. 1968 Mar;49(3):301–311. doi: 10.1093/ajcp/49.3.301. [DOI] [PubMed] [Google Scholar]

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