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. 1993 Sep;31(9):2506–2508. doi: 10.1128/jcm.31.9.2506-2508.1993

Genomic fingerprinting of Neisseria meningitidis associated with group C meningococcal disease in Canada.

C A Strathdee 1, S D Tyler 1, J A Ryan 1, W M Johnson 1, F E Ashton 1
PMCID: PMC265787  PMID: 8408577

Abstract

A single electrophoretic type (ET15) of Neisseria meningitidis has been associated with an increased incidence of group C meningococcal disease in Canada. Genomic fingerprinting through pulsed-field gel electrophoresis of chromosomal DNA was used to characterize the clonal relationship among meningococcal isolates of different electrophoretic types and among isolates within ET15. The genomic fingerprints of the ET15 isolates, while similar as a group, were sufficiently distinct to confirm linkage for four pairs of strains from focal outbreaks and differed markedly from those of the other common electrophoretic types, ET5, ET9, and ET21.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ashton F. E., Mancino L., Ryan A. J., Poolman J. T., Abdillahi H., Zollinger W. D. Serotypes and subtypes of Neisseria meningitidis serogroup B strains associated with meningococcal disease in Canada, 1977-1989. Can J Microbiol. 1991 Aug;37(8):613–617. doi: 10.1139/m91-104. [DOI] [PubMed] [Google Scholar]
  2. Ashton F. E., Ryan J. A., Borczyk A., Caugant D. A., Mancino L., Huang D. Emergence of a virulent clone of Neisseria meningitidis serotype 2a that is associated with meningococcal group C disease in Canada. J Clin Microbiol. 1991 Nov;29(11):2489–2493. doi: 10.1128/jcm.29.11.2489-2493.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bygraves J. A., Maiden M. C. Analysis of the clonal relationships between strains of Neisseria meningitidis by pulsed field gel electrophoresis. J Gen Microbiol. 1992 Mar;138(3):523–531. doi: 10.1099/00221287-138-3-523. [DOI] [PubMed] [Google Scholar]
  4. Caugant D. A., Zollinger W. D., Mocca L. F., Frasch C. E., Whittam T. S., Frøholm L. O., Selander R. K. Genetic relationships and clonal population structure of serotype 2 strains of Neisseria meningitidis. Infect Immun. 1987 Jun;55(6):1503–1512. doi: 10.1128/iai.55.6.1503-1512.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gemmill I. An outbreak of meningococcal disease in Ottawa-Carleton. December 1991-February 1992. Can J Public Health. 1992 Mar-Apr;83(2):134–137. [PubMed] [Google Scholar]
  6. Heimann G. A., Mikel D. E., Naus M., Goel V., Tischler M., Carlson J. A., Schabas R., Pasut G., Borczyk A., Krishnan C. Meningococcal disease in Ontario during the winter of 1988-1989. Can Dis Wkly Rep. 1989 Mar 18;15(11):59–62. [PubMed] [Google Scholar]
  7. KELLOGG D. S., Jr, PEACOCK W. L., Jr, DEACON W. E., BROWN L., PIRKLE D. I. NEISSERIA GONORRHOEAE. I. VIRULENCE GENETICALLY LINKED TO CLONAL VARIATION. J Bacteriol. 1963 Jun;85:1274–1279. doi: 10.1128/jb.85.6.1274-1279.1963. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Taylor D. E., Eaton M., Yan W., Chang N. Genome maps of Campylobacter jejuni and Campylobacter coli. J Bacteriol. 1992 Apr;174(7):2332–2337. doi: 10.1128/jb.174.7.2332-2337.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Varughese P. V., Carter A. O. Meningococcal disease in Canada. Surveillance summary to 1987. Can Dis Wkly Rep. 1989 Apr 29;15(17):89–96. [PubMed] [Google Scholar]

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