Abstract
Antigenic types of 113 strains of Rickettsia tsutsugamushi isolated from Korean patients were analyzed by using murine polyclonal and monoclonal antibodies. The isolates can be classified in six groups according to their reaction to a panel of monoclonal antibodies. Nine isolates of group I were identified as the Gilliam serotype, and 13 isolates of groups II and III were identified as the Karp serotype. There were two groups that were considered to be a mixture of groups I and II or groups I and III, respectively. The remaining 88 strains of group IV had a unique antigenic determinant that was not present in the prototype strains (Karp, Kato, Gilliam), in addition to sharing common antigens with the prototype strains. Therefore these strains, which are more prevalent in Korea, seem to belong to a new serotype closely related to the Karp serotype.
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- BOZEMAN F. M., ELISBERG B. L. Serological diagnosis of scrub typhus by indirect immunofluorescence. Proc Soc Exp Biol Med. 1963 Mar;112:568–573. doi: 10.3181/00379727-112-28107. [DOI] [PubMed] [Google Scholar]
- Eisemann C. S., Osterman J. V. Identification of strain-specific and group-reactive antigenic determinants on the Karp, Gilliam and Kato strains of Rickettsia tsutsugamushi. Am J Trop Med Hyg. 1985 Nov;34(6):1173–1178. doi: 10.4269/ajtmh.1985.34.1173. [DOI] [PubMed] [Google Scholar]
- Elisberg B. L., Campbell J. M., Bozeman F. M. Antigenic diversity of rickettsia tsutsugamushi: epidemiologic and ecologic significance. J Hyg Epidemiol Microbiol Immunol. 1968;12(1):18–25. [PubMed] [Google Scholar]
- Iida T., Kawashima H., Kawamura A. Direct immunofluorescence for typing of tsutsugamushi disease rickettsia. J Immunol. 1965 Dec;95(6):1129–1133. [PubMed] [Google Scholar]
- Kanemitsu N. [Production and characterization of the monoclonal antibodies to Rickettsia tsutsugamushi]. Kansenshogaku Zasshi. 1987 Jul;61(7):819–829. doi: 10.11150/kansenshogakuzasshi1970.61.819. [DOI] [PubMed] [Google Scholar]
- Köhler G., Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature. 1975 Aug 7;256(5517):495–497. doi: 10.1038/256495a0. [DOI] [PubMed] [Google Scholar]
- SHISHIDO A. STRAIN VARIATION OF RICKETTSIA ORIENTALIS IN THE COMPLEMENT FIXATION TEST. Jpn J Med Sci Biol. 1964 Jun;17:59–72. doi: 10.7883/yoken1952.17.59. [DOI] [PubMed] [Google Scholar]
- Shirai A., Coolbaugh J. C., Gan E., Chan T. C., Huxsoll D. L., Groves M. G. Serologic analysis of scrub typhus isolates from the Pescadores and Philippine Islands. Jpn J Med Sci Biol. 1982 Oct-Dec;35(5-6):255–259. doi: 10.7883/yoken1952.35.255. [DOI] [PubMed] [Google Scholar]
- Shirai A., Robinson D. M., Brown G. W., Gan E., Huxsoll D. L. Antigenic analysis by direct immunofluorescence of 114 isolates of Rickettsia tsutsugamushi recovered from febrile patients in rural Malaysia. Jpn J Med Sci Biol. 1979 Dec;32(6):337–344. doi: 10.7883/yoken1952.32.337. [DOI] [PubMed] [Google Scholar]
- Tamura A., Takahashi K., Tsuruhara T., Urakami H., Miyamura S., Sekikawa H., Kenmotsu M., Shibata M., Abe S., Nezu H. Isolation of Rickettsia tsutsugamushi antigenically different from Kato, Karp, and Gilliam strains from patients. Microbiol Immunol. 1984;28(8):873–882. doi: 10.1111/j.1348-0421.1984.tb00743.x. [DOI] [PubMed] [Google Scholar]
- Traub R., Wisseman C. L., Jr Ecological considerations in scrub typhus. 1. Emerging concepts. Bull World Health Organ. 1968;39(2):209–218. [PMC free article] [PubMed] [Google Scholar]
- Yamamoto S., Kawabata N., Tamura A., Urakami H., Ohashi N., Murata M., Yoshida Y., Kawamura A., Jr Immunological properties of Rickettsia tsutsugamushi, Kawasaki strain, isolated from a patient in Kyushu. Microbiol Immunol. 1986;30(7):611–620. doi: 10.1111/j.1348-0421.1986.tb02988.x. [DOI] [PubMed] [Google Scholar]