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. 1987 Dec;25(12):2415–2417. doi: 10.1128/jcm.25.12.2415-2417.1987

Antibody that inhibits human immunodeficiency virus reverse transcriptase and association with inability to isolate virus.

K Sano 1, M H Lee 1, F Morales 1, P Nishanian 1, J Fahey 1, R Detels 1, D T Imagawa 1
PMCID: PMC269505  PMID: 2448336

Abstract

Most individuals infected with human immunodeficiency virus (HIV), the causative agent of acquired immune deficiency syndrome, produce an antibody against the viral reverse transcriptase (RT). Our studies show that 67% of HIV-seropositive individuals (33 of 49) produced an antibody that specifically inhibited viral RT enzyme activity. We were able to isolate HIV from only 18% of these individuals (6 of 33). On the other hand, virus was readily isolated from 63% of HIV-seropositive individuals (10 of 16) who did not demonstrate this antibody. Further examination of this RT-inhibiting antibody and its role during virus infection is needed, as it may prove to be of diagnostic, prognostic, or therapeutic value in this study and treatment of acquired immune deficiency syndrome.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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