Skip to main content
PMC home page
Journal of Clinical Microbiology logoLink to Journal of Clinical Microbiology
. 1985 May;21(5):764–767. doi: 10.1128/jcm.21.5.764-767.1985

Serological diagnosis of Staphylococcus aureus osteomyelitis.

L J Wheat, A C White, C Norden
PMCID: PMC271776  PMID: 3998107

Abstract

We have evaluated serological tests for the diagnosis of Staphylococcus aureus osteomyelitis. Antiteichoic acid antibodies were elevated in 17 of 23 patients with acute and 16 of 46 with chronic S. aureus osteomyelitis but in none of 33 patients infected with other gram-positive or gram-negative bacteria. Immunoglobulin G antibodies to S. aureus were elevated in 12 of 23 patients with acute and 22 of 47 with chronic S. aureus osteomyelitis, in 2 of 12 infected with other gram-positive bacteria, and in 4 of 21 with other gram-negative bacteria. Assays for S. aureus antibodies may be useful for identifying patients with S. aureus bacteremia complicated by metastatic sites of infection in bone and for identifying the etiological agents in patients with negative or mixed cultures or from whom cultures are not readily available. Prospective studies are needed to test these hypotheses.

Full text

PDF
764

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cole W. G., Dalziel R. E., Leitl S. Treatment of acute osteomyelitis in childhood. J Bone Joint Surg Br. 1982;64(2):218–223. doi: 10.1302/0301-620X.64B2.6802854. [DOI] [PubMed] [Google Scholar]
  2. Crowder J. G., White A. Teichoic acid antibodies in staphylococcal and nonstaphylococcal endocarditis. Ann Intern Med. 1972 Jul;77(1):87–90. doi: 10.7326/0003-4819-77-1-87. [DOI] [PubMed] [Google Scholar]
  3. Dich V. Q., Nelson J. D., Haltalin K. C. Osteomyelitis in infants and children. A review of 163 cases. Am J Dis Child. 1975 Nov;129(11):1273–1278. doi: 10.1001/archpedi.1975.02120480007004. [DOI] [PubMed] [Google Scholar]
  4. HARRIS N. H. Some problems in the diagnosis and treatment of acute osteomyelitis. J Bone Joint Surg Br. 1960 Aug;42-B:535–541. doi: 10.1302/0301-620X.42B3.535. [DOI] [PubMed] [Google Scholar]
  5. Mackowiak P. A., Jones S. R., Smith J. W. Diagnostic value of sinus-tract cultures in chronic osteomyelitis. JAMA. 1978 Jun 30;239(26):2772–2775. doi: 10.1001/jama.239.26.2772. [DOI] [PubMed] [Google Scholar]
  6. Nagel J. G., Tuazon C. U., Cardella T. A., Sheagren J. N. Teichoic acid serologic diagnosis of staphylococcal endocarditis. Use of gel diffusion and counterimmunoelectrophoretic methods. Ann Intern Med. 1975 Jan;82(1):13–17. doi: 10.7326/0003-4819-82-1-13. [DOI] [PubMed] [Google Scholar]
  7. Sheagren J. N. Guidelines for the use of the teichoic acid antibody assay. Arch Intern Med. 1984 Feb;144(2):250–252. [PubMed] [Google Scholar]
  8. Sugarman B., Hawes S., Musher D. M., Klima M., Young E. J., Pircher F. Osteomyelitis beneath pressure sores. Arch Intern Med. 1983 Apr;143(4):683–688. [PubMed] [Google Scholar]
  9. Tuazon C. U., Perez A., Kishaba T., Sheagren J. N. Staphylococcus aureus among insulin-injecting diabetic patients. An increased carrier rate. JAMA. 1975 Mar 24;231(12):1272–1272. [PubMed] [Google Scholar]
  10. Tuazon C. U., Sheagren J. N., Choa M. S., Marcus D., Curtin J. A. Staphylococcus aureus bacteremia: relationship between formation of antibodies to teichoic acid and development of metastatic abscesses. J Infect Dis. 1978 Jan;137(1):57–62. doi: 10.1093/infdis/137.1.57. [DOI] [PubMed] [Google Scholar]
  11. Tuazon C. U., Sheagren J. N. Increased rate of carriage of Staphylococcus aureus among narcotic addicts. J Infect Dis. 1974 Jun;129(6):725–727. doi: 10.1093/infdis/129.6.725. [DOI] [PubMed] [Google Scholar]
  12. Tuazon C. U., Sheagren J. N. Teichoic acid antibodies in the diagnosis of serious infections with Staphylococcus aureus. Ann Intern Med. 1976 May;84(5):543–546. doi: 10.7326/0003-4819-84-5-543. [DOI] [PubMed] [Google Scholar]
  13. Waldvogel F. A., Medoff G., Swartz M. N. Osteomyelitis: a review of clinical features, therapeutic considerations and unusual aspects (second of three parts). N Engl J Med. 1970 Jan 29;282(5):260–266. doi: 10.1056/NEJM197001292820507. [DOI] [PubMed] [Google Scholar]
  14. Waldvogel F. A., Papageorgiou P. S. Osteomyelitis: the past decade. N Engl J Med. 1980 Aug 14;303(7):360–370. doi: 10.1056/NEJM198008143030703. [DOI] [PubMed] [Google Scholar]
  15. Wheat J., Kohler R. B., Garten M., White A. Commercially available (ENDO-STAPH) assay for teichoic acid antibodies. Evaluation in patients with serious Staphylococcus aureus infections and in controls. Arch Intern Med. 1984 Feb;144(2):261–264. [PubMed] [Google Scholar]
  16. Wheat L. J., Kohler R. B., Tabarah Z. A., White A. IgM antibody response to staphylococcal infection. J Infect Dis. 1981 Oct;144(4):307–311. doi: 10.1093/infdis/144.4.307. [DOI] [PubMed] [Google Scholar]
  17. Wheat L. J., Kohler R. B., White A. Solid-phase radioimmunoassay for immunoglobulin G Staphylococcus aureus antibody in serious staphylococcal infection. Ann Intern Med. 1978 Oct;89(4):467–472. doi: 10.7326/0003-4819-89-4-467. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Microbiology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES