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. 1983 Nov;18(5):1146–1149. doi: 10.1128/jcm.18.5.1146-1149.1983

Serum immunoglobulin A antibody to varicella-zoster virus in subjects with primary varicella and herpes zoster infections and in immune subjects.

A E Wittek, A M Arvin, C M Koropchak
PMCID: PMC272858  PMID: 6315766

Abstract

Immunoglobulin A (IgA) antibodies to varicella-zoster virus (VZV) were measured in sera from subjects with acute varicella and herpes zoster, VZV-immune subjects remote from infection, and recipients of a live attenuated varicella vaccine, using a solid-phase radioimmunoassay. Primary infection with VZV was associated with early production of IgA antibodies. Among 36 subjects with varicella tested 1 to 5 days after onset, 22 had detectable IgA, and all of the negative sera were obtained before day 3 of the varicella exanthem. VZV IgA was detected in one of three sera obtained more than 60 days after onset of the illness. Four of five sera obtained from subjects within 1 week of the onset of herpes zoster had measurable levels of IgA. Between 1 and 4 weeks after onset of zoster, all 10 subjects tested had detectable IgA to VZV. VZV IgA was detected as late as 63 days after the onset of herpes zoster. Of 10 vaccine recipients, 5 developed VZV IgA which was detected as early as 4 weeks and persisted for as long as 16 weeks after vaccination. VZV IgA was not detected in sera from 42 children who had no detectable IgG antibody to VZV. VZV IgA was found on only 3 of 23 sera from adults who had varicella more than 20 years before.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arvin A. M., Koropchak C. M. Immunoglobulins M and G to varicella-zoster virus measured by solid-phase radioimmunoassay: antibody responses to varicella and herpes zoster infections. J Clin Microbiol. 1980 Sep;12(3):367–374. doi: 10.1128/jcm.12.3.367-374.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Arvin A. M., Koropchak C. M., Wittek A. E. Immunologic evidence of reinfection with varicella-zoster virus. J Infect Dis. 1983 Aug;148(2):200–205. doi: 10.1093/infdis/148.2.200. [DOI] [PubMed] [Google Scholar]
  3. Asano Y., Takahashi M. Clinical and serologic testing of a live varicella vaccine and two-year follow-up for immunity of the vaccinated children. Pediatrics. 1977 Dec;60(6):810–814. [PubMed] [Google Scholar]
  4. Bogger-Goren S., Baba K., Hurley P., Yabuuchi H., Takahashi M., Ogra P. L. Antibody response to varicella-zoster virus after natural or vaccine-induced infection. J Infect Dis. 1982 Aug;146(2):260–265. doi: 10.1093/infdis/146.2.260. [DOI] [PubMed] [Google Scholar]
  5. Brunell P. A., Gershon A. A., Uduman S. A., Steinberg S. Varicella-Zoster Immunoglobulins during Varicella, Latency, and Zoster. J Infect Dis. 1975 Jul;132(1):49–54. doi: 10.1093/infdis/132.1.49. [DOI] [PubMed] [Google Scholar]
  6. Campbell-Benzie A., Kangro H. O., Heath R. B. The development and evaluation of a solid-phase radioimmunoassay (RIA) procedure for the determination of susceptibility to varicella. J Virol Methods. 1981 Feb;2(3):149–158. doi: 10.1016/0166-0934(81)90033-1. [DOI] [PubMed] [Google Scholar]
  7. Feldman S., Hughes W. T., Daniel C. B. Varicella in children with cancer: Seventy-seven cases. Pediatrics. 1975 Sep;56(3):388–397. [PubMed] [Google Scholar]
  8. Friedman M. G., Kimmel N. Herpes simplex virus-specific serum immunoglobulin a: detection in patients with primary or recurrent herpes infections and in healthy adults. Infect Immun. 1982 Jul;37(1):374–377. doi: 10.1128/iai.37.1.374-377.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Gershon A. A. Live attenuated Varicella-Zoster vaccine. Rev Infect Dis. 1980 May-Jun;2(3):393–407. doi: 10.1093/clinids/2.3.393. [DOI] [PubMed] [Google Scholar]
  10. Ha K., Baba K., Ikeda T., Nishida M., Yabuuchi H., Takahashi M. Application of live varicella vaccine to children with acute leukemia or other malignancies without suspension of anticancer therapy. Pediatrics. 1980 Feb;65(2):346–350. [PubMed] [Google Scholar]
  11. Halonen P., Meurman O., Matikainen M. T., Torfason E., Bennich H. IgA antibody response in acute rubella determined by solid-phase radioimmunoassay. J Hyg (Lond) 1979 Aug;83(1):69–75. doi: 10.1017/s0022172400025833. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Izawa T., Ihara T., Hattori A., Iwasa T., Kamiya H., Sakurai M., Takahashi M. Application of a live varicella vaccine in children with acute leukemia or other malignant diseases. Pediatrics. 1977 Dec;60(6):805–809. [PubMed] [Google Scholar]
  13. Levy E., Sarov I. Detection of specific IgA antibodies in serum of patients with varicella and zoster infections. Intervirology. 1981;15(2):103–110. doi: 10.1159/000149220. [DOI] [PubMed] [Google Scholar]
  14. Nikoskelainen J., Neel E. U., Stevens D. A. Epstein-Barr virus-specific serum immunoglobulin A as an acute-phase antibody in infectious mononucleosis. J Clin Microbiol. 1979 Jul;10(1):75–79. doi: 10.1128/jcm.10.1.75-79.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Preblud S. R. Age-specific risks of varicella complications. Pediatrics. 1981 Jul;68(1):14–17. [PubMed] [Google Scholar]
  16. Sarov I., Levy E., Aymard M., Chardonnet Y., Bosshard S., Revillard J. P., Friedman M., Nord E., Greiff M., Haikin H. Detection of virus-specific IgA antibodies in serum of kidney transplant patients with recurrent cytomegalovirus infection by enzymeimmuno and radioimmunoassay techniques. Clin Exp Immunol. 1982 May;48(2):321–328. [PMC free article] [PubMed] [Google Scholar]

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