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. 1976 Sep;4(3):306–308. doi: 10.1128/jcm.4.3.306-308.1976

Immune Response to Acute Otitis Media: Association Between Middle Ear Fluid Antibody and the Clearing of Clinical Infection

John L Sloyer Jr *, Virgil M Howie †,‡, John H Ploussard †,‡, Gerald Schiffman †,‡, Richard B Johnston Jr †,‡
PMCID: PMC274454  PMID: 9424

Abstract

Clearing of the middle ear fluid in patients with acute otitis media due to Streptococcus pneumoniae or Haemophilus influenzae was significantly associated with the presence and concentration of specific antibody in the middle ear fluid at the time of diagnosis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Butler W. T., Rossen R. D., Wenden R. D. Effect of physical state and route of inoculation of diphtheria toxoid on the formation of nasal secretory and serum antibodies in man. J Immunol. 1970 Jun;104(6):1396–1400. [PubMed] [Google Scholar]
  2. Howie V. M., Ploussard J. H., Sloyer J. L., Johnston R. B., Jr Immunoglobulins of the middle ear fluid in acute otitis media: relationship to serum immunoglobulin concentrations and bacterial cultures. Infect Immun. 1973 Apr;7(4):589–593. doi: 10.1128/iai.7.4.589-593.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Howie V. M., Ploussard J. H. The "in vivo sensitivity test"--bacteriology of middle ear exudate, during antimicrobial therapy in otitis media. Pediatrics. 1969 Dec;44(6):940–944. [PubMed] [Google Scholar]
  4. Lim D. J., Viall J., Birck H., St Pierre R. The morphological basis for understanding middle ear effusions. An electron microscopic, cytochemical, and autoradiographic investigation. Laryngoscope. 1972 Sep;82(9):1625–1642. doi: 10.1288/00005537-197209000-00006. [DOI] [PubMed] [Google Scholar]
  5. Mogi G., Honjo S., Maeda S., Yoshida T. Secretory immunoglobulin A (SIgA) in middle ear effusions. Observation of 160 specimens. Ann Otol Rhinol Laryngol. 1973 May-Jun;82(3):302–310. doi: 10.1177/000348947308200306. [DOI] [PubMed] [Google Scholar]
  6. Newcomb R. W., Ishizaka K., DeVald B. L. Human IgG and IgA diphtheria antitoxins in serum, nasal fluids and saliva. J Immunol. 1969 Aug;103(2):215–224. [PubMed] [Google Scholar]
  7. Ogra P. L., Bernstein J. M., Yurchak A. M., Coppola P. R., Tomasi T. B., Jr Characteristics of secretory immune system in human middle ear: implications in otitis media. J Immunol. 1974 Feb;112(2):488–495. [PubMed] [Google Scholar]
  8. Sloyer J. L., Jr, Cate C. C., Howie V. M., Ploussard J. H., Johnston R. B., Jr The immune response to acute otitis media in children. II. Serum and middle ear fluid antibody in otitis media due to Haemophilus influenza. J Infect Dis. 1975 Dec;132(6):685–688. doi: 10.1093/infdis/132.6.685. [DOI] [PubMed] [Google Scholar]
  9. Sloyer J. L., Jr, Howie V. M., Ploussard J. H., Ammann A. J., Austrian R., Johnston R. B., Jr Immune response to acute otitis media in children. I. Serotypes isolated and serum and middle ear fluid antibody in pneumococcal otitis media. Infect Immun. 1974 Jun;9(6):1028–1032. doi: 10.1128/iai.9.6.1028-1032.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Veltri R. W., Sprinkle P. M. Serous otitis media. Immunoglobulin and lysozyme levels in middle ear fluids and serum. Ann Otol Rhinol Laryngol. 1973 May-Jun;82(3):297–301. doi: 10.1177/000348947308200305. [DOI] [PubMed] [Google Scholar]

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