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. 1976 Oct;4(4):338–342. doi: 10.1128/jcm.4.4.338-342.1976

Immunoglobulin specificity for the fluorescent treponemal antibody-absorption test conjugate.

E F Hunter, S E Maddison, S A Larsen, M B Felker, J C Feeley
PMCID: PMC274469  PMID: 789394

Abstract

Quantitative indirect immunofluorescence tests have demonstrated the predominance of immunoglobulin G antibody in most stages of syphilis. A class-specific anti-human immunoglobulin G conjugate is recommended to replace the present fluorescent treponemal antibody-absorption test conjugate. This would allow further definition and standardization of the fluorescent treponemal antibody-absorption test.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Atwood W. G., Miller J. L. Fluorescent treponemal antibodies in fractionated syphilitic sera. The immunoglobulin class. Arch Dermatol. 1969 Dec;100(6):763–769. [PubMed] [Google Scholar]
  2. Brighton W. D., Taylor C. E., Tomlinson A. H., Wilkinson A. E. A provisional specification for fluorescein-labelled antibody against human globulin (IgG). Mon Bull Minist Health Public Health Lab Serv. 1967 Sep;26:179–181. [PubMed] [Google Scholar]
  3. Brown W. J., Kuhn U. S., Tolliver E. A., Norins L. C. Experimental syphilis in the chimpanzee. Immunoglobulin class of early antibodies reactive with Treponema pallidum. Br J Vener Dis. 1970 Jun;46(3):198–200. doi: 10.1136/sti.46.3.198. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. DEACON W. E., FREEMAN E. M., HARRIS A. Fluorescent treponemal antibody test. Modification based on quantitation (FTA-200). Proc Soc Exp Biol Med. 1960 Apr;103:827–829. doi: 10.3181/00379727-103-25685. [DOI] [PubMed] [Google Scholar]
  5. Hardy P. H., Nell E. E. Characteristics of fluorescein labelled antiglobulin preparations that may affect the fluorescent treponemal antibody-absorption test. Am J Clin Pathol. 1971 Aug;56(2):181–186. doi: 10.1093/ajcp/56.2.181. [DOI] [PubMed] [Google Scholar]
  6. Hunter E. F., Creighton E. T., Lewis J. S. An improved antigen for the FTA-ABS test. Health Lab Sci. 1970 Oct;7(4):237–241. [PubMed] [Google Scholar]
  7. Hunter E. F., Smith J. F., Lewis J. S., McGrew B. E., Schmale J. D. Immunochemical parameters of some commercial conjugates for the fluorescent treponemal antibody-absorption test. Infect Immun. 1972 Jun;5(6):858–862. doi: 10.1128/iai.5.6.858-862.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hunter E. F. The fluorescent treponemal antibody-absorption (FTA-ABS) test for syphilis. CRC Crit Rev Clin Lab Sci. 1975 Jan;5(3):315–330. doi: 10.3109/10408367509107046. [DOI] [PubMed] [Google Scholar]
  9. Jobbágy A. Distribution of syphilitic antibodies in gel-filtered serum fractions. Br J Vener Dis. 1970 Dec;46(6):445–450. [PMC free article] [PubMed] [Google Scholar]
  10. Julian A. J., Logan L. C., Norins L. C. Early syphilis: immunoglobulins reactive in immunofluorescence and other serologic tests. J Immunol. 1969 May;102(5):1250–1259. [PubMed] [Google Scholar]
  11. Julian A. J., Logan L. C., Norins L. C., Scotti A. T. Latent syphilis: immunoglobulins reactive in immunofluorescence and other serological tests. Infect Immun. 1971 Apr;3(4):559–561. doi: 10.1128/iai.3.4.559-561.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Kaufman R. E., Feeley J. C., Reynolds G. H. Letter: Early-warning test for syphilis. Lancet. 1974 Feb 2;1(7849):163–163. doi: 10.1016/s0140-6736(74)92450-7. [DOI] [PubMed] [Google Scholar]
  13. Király K., Backhausz R., Jobbágy A., Lajos J., Kováts L. Fluorescent treponemal antibody test with antihuman immune sera of different specificity. Acta Derm Venereol. 1968;48(4):362–369. [PubMed] [Google Scholar]
  14. Király K., Jobbágy A., Kováts L. Group antibodies in fluorescent treponemal antibody (FTA) test. J Invest Dermatol. 1967 Jan;48(1):98–100. doi: 10.1038/jid.1967.15. [DOI] [PubMed] [Google Scholar]
  15. Király K., Jobbágy A., Mecher T. Fluorescent treponemal antibody testing. Bull World Health Organ. 1965;33(5):687–703. [PMC free article] [PubMed] [Google Scholar]
  16. Logan L. C., Norins L. C., Atwood W. G., Miller J. L. Treated late syphilis: immunoglobulin class of antibodies reactive with Treponema pallidum. J Invest Dermatol. 1969 Oct;53(4):300–301. doi: 10.1038/jid.1969.151. [DOI] [PubMed] [Google Scholar]
  17. Manikowska-Lesińska W., Jakubowski A. Relationship of antibodies detected by the immunofluorescence method with the various classes of immunoglobulins in cases of untreated syphilis. Br J Vener Dis. 1970 Oct;46(5):380–382. doi: 10.1136/sti.46.5.380. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Matuhasi T., Mizuoka K., Usui M. Studies on the fluorescent treponemal antibody test using fluorescent anti-gamma, anti-alpha, anti-mu, anti-lambda, anti-kappa chains and beta-1CA, E globulin reagents. Bull World Health Organ. 1966;34(3):466–472. [PMC free article] [PubMed] [Google Scholar]
  19. O'Neill P., Nicol C. S. IgM class antitreponemal antibody in treated and untreated syphilis. Br J Vener Dis. 1972 Dec;48(6):460–463. doi: 10.1136/sti.48.6.460. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Puritz E. M., Thompson J. A., Jr, Dierberg F., Kraus S. J., Yount W. J. IgG subclasses of fluorescent treponemal antibodies: correlation with complement fixation and clinical stage. Clin Immunol Immunopathol. 1975 Sep;4(3):352–361. doi: 10.1016/0090-1229(75)90004-5. [DOI] [PubMed] [Google Scholar]
  21. Reimer C. B., Black C. M., Phillips D. J., Logan L. C., Hunter E. F., Pender B. J., McGrew B. E. The specificity of fetal IgM: antibody or anti-antibody? Ann N Y Acad Sci. 1975 Jun 30;254:77–93. doi: 10.1111/j.1749-6632.1975.tb29159.x. [DOI] [PubMed] [Google Scholar]
  22. Reimer C. B., Phillips D. J., Maddison S. E., Shore S. L. Comparative evaluation of commercial precipitating antisera against human IgM and IgM. J Lab Clin Med. 1970 Dec;76(6):949–960. [PubMed] [Google Scholar]
  23. Wilkinson A. E., Johnston N. A. A comparison between sorbent and Reiter sonicate in the absorbed fluorescent treponemal antibody test. Ann N Y Acad Sci. 1975 Jun 30;254:395–399. doi: 10.1111/j.1749-6632.1975.tb29190.x. [DOI] [PubMed] [Google Scholar]

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