Abstract
The "R-75" strain live, attenuated, serum inhibitor-resistant influenza B vaccine was administered intranasally by drops in two doses 14 days apart to 21 volunteers. Each vaccinee was paired with a close associate (roommate or workmate) who similarly received two doses of a placebo solution. Although about 50% of both vaccine and placebo recipients complained of symptoms after dosage, the severity of symptoms was greater in vaccine recipients. Fourfold serum hemagglutination-inhibiting antibody titer rises occurred in 38% of vaccine recipients, and four vaccines had fourfold titer rises of nasal hemagglutination-inhibiting antibody. Vaccine virus was isolated from three asymptomatic vaccine recipients. There was no virological or serological evidence of the vaccine virus spreading to placebo recipients.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Beare A. S., Bynoe M. L., Tyrrell D. A. Investigetion into the attenuation of influenza viruses by serial passage. Br Med J. 1968 Nov 23;4(5629):482–484. doi: 10.1136/bmj.4.5629.482. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Beare A. S., Hobson D., Reed S. E., Tyrrell D. A. A comparison of live and killed influenza-virus vaccines. Report to the Medical Research Council's Committee on Influenza and other Respiratory Virus Vaccines. Lancet. 1968 Aug 24;2(7565):418–422. doi: 10.1016/s0140-6736(68)90463-7. [DOI] [PubMed] [Google Scholar]
- Beare A. S., Maassab H. F., Tyrrell D. A., Slepuskin A. N., Hall T. S. A comparative study of attenuated influenza viruses. Bull World Health Organ. 1971;44(5):593–598. [PMC free article] [PubMed] [Google Scholar]
- Beare A. S., Tyrrell D. A., Hobson D., Howells C. H., Pereira M. S., Pollock T. M., Tyler L. E. Live influenza B vaccine in volunteers. A report to the Medical Research Council by their Committee on Influenza and Other Respiratory Virus Vaccines. J Hyg (Lond) 1969 Mar;67(1):1–11. doi: 10.1017/s002217240004136x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Downie J. C., Stuart-Harris C. H. The production of neutralizing activity in serum and nasal secretion following immunization with influenza B virus. J Hyg (Lond) 1970 Jun;68(2):233–244. doi: 10.1017/s0022172400028709. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Spencer M. J., Cherry J. D., Powell K. R., Sumaya C. V., Garakian A. J. Clinical trials with Alice strain, live, attenuated, serum inhibitor-resistant intranasal influenza A vaccine. J Infect Dis. 1975 Oct;132(4):415–420. doi: 10.1093/infdis/132.4.415. [DOI] [PubMed] [Google Scholar]