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. 1975 Mar;1(3):298–301. doi: 10.1128/jcm.1.3.298-301.1975

Antibody response of patients with malignancies to bacteremia with gram-negative bacteria.

M J Surgalla, E Neter, J E Fitzpatrick
PMCID: PMC275066  PMID: 1100659

Abstract

Antibody response, determined by means of the indirect bacterial hemagglutination tests, was studied in 58 consecutive patients with various malignancies whose blood culture yielded growth of Enterobacteriaceae or Pseudomonas and from whom serum specimens were obtained. Of these patients 59% had a significant antibody response. The invading microorganisms were Escherichia coli in 33 and Klebsiella in 19 subjects, an antibody response being documented with essentially equal frequency (60 and 57% of the subjects, respectively). Two patients had positive blood cultures for both E. coli and Klebsiella, one of whom had a significant response to one isolate only. A specific antibody resonse was documented in 67% of the subjects from whom blood for antibody titration was obtained at least 5 days after the blood culture, but from only 21% of patients whose serum was procured during the first 5 days after the blood culture. Similarly, such an antibody response was identified in 73% of subjects with two consecutive serum specimens, but in only 28% of the patients with a single serum specimen for antibody titration. Documentation of the immune response may be of diagnostic aid in differentiating between infection and contamination even in patients with underlying malignancy and under potentially immunosuppressive therapy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aisenberg A. C. Manifestations of immunologic unresponsiveness in Hodgkin's disease. Cancer Res. 1966 Jun;26(6):1152–1164. [PubMed] [Google Scholar]
  2. Armstrong D., Young L. S., Meyer R. D., Blevins A. H. Infectious complications of neoplastic disease. Med Clin North Am. 1971 May;55(3):729–745. doi: 10.1016/s0025-7125(16)32514-7. [DOI] [PubMed] [Google Scholar]
  3. Ceglowski W. S., Friedman H. Immunosuppressive effects of Friend and Rauscher leukemia disease viruses on cellular and humoral antibody formation. J Natl Cancer Inst. 1968 May;40(5):983–995. [PubMed] [Google Scholar]
  4. Diaz E., Mosovich L. L., Neter E. Serogroups of Pseudomonas aeruginosa and the immune response of patients with cystic fibrosis. J Infect Dis. 1970 Mar;121(3):269–274. doi: 10.1093/infdis/121.3.269. [DOI] [PubMed] [Google Scholar]
  5. Diaz F., Neter E. Pseudomonas aeruginosa: serogroups and antibody response in patients with neoplastic diseases. Am J Med Sci. 1970 May;259(5):340–345. [PubMed] [Google Scholar]
  6. Feld R., Bodey G. P., Rodriguez V., Luna M. Causes of death in patients with malignant lymphoma. Am J Med Sci. 1974 Aug;268(2):97–106. doi: 10.1097/00000441-197408000-00003. [DOI] [PubMed] [Google Scholar]
  7. GELLER W. A study of antibody formation in patients with malignant lymphomas. J Lab Clin Med. 1953 Aug;42(2):232–237. [PubMed] [Google Scholar]
  8. GORZYNSKI E. A., LUDERITZ O., NETER E., WESTPHAL O. The bacterial hemagglutination test for the demonstration of antibodies to Enterobacteriaceae. Ann N Y Acad Sci. 1956 Aug 10;66(1):141–156. doi: 10.1111/j.1749-6632.1956.tb40113.x. [DOI] [PubMed] [Google Scholar]
  9. Hughes W. T., Feldman S., Cox F. Infectious diseases in children with cancer. Pediatr Clin North Am. 1974 Aug;21(3):583–615. doi: 10.1016/s0031-3955(16)33027-9. [DOI] [PubMed] [Google Scholar]
  10. Inagaki J., Rodriguez V., Bodey G. P. Proceedings: Causes of death in cancer patients. Cancer. 1974 Feb;33(2):568–573. doi: 10.1002/1097-0142(197402)33:2<568::aid-cncr2820330236>3.0.co;2-2. [DOI] [PubMed] [Google Scholar]
  11. Klastersky J., Daneau D., Verhest A. Causes of death in patients with cancer. Eur J Cancer. 1972 Apr;8(2):149–154. doi: 10.1016/0014-2964(72)90036-9. [DOI] [PubMed] [Google Scholar]
  12. NETER E., DRISLANE A. M., HARRIS A. H., JANSEN G. T. Diagnosis of clinical and subclinical salmonellosis by means of a serologic hemagglutination test. N Engl J Med. 1959 Dec 3;261:1162–1165. doi: 10.1056/NEJM195912032612305. [DOI] [PubMed] [Google Scholar]
  13. NETER E., GORZYNSKI E. A., GINO R. M., WESTPHAL O., LUDERITZ O. The enterobacterial hemagglutination test and its diagnostic potentialities. Can J Microbiol. 1956 May;2(3):232–244. doi: 10.1139/m56-028. [DOI] [PubMed] [Google Scholar]
  14. Neter E., Merrin C., Surgalla M. J., Wajsman Z. Shigella sonnei bacteremia. Unusual antibody response from immunosuppressive therapy following renal transplantation. Urology. 1974 Aug;4(2):198–200. doi: 10.1016/0090-4295(74)90333-1. [DOI] [PubMed] [Google Scholar]
  15. Neter E., Oberkircher O. R., Rubin M. I., Steinhart J. M., Krzeska I. Patterns of antibody response of children with infections of the urinary tract. Pediatr Res. 1970 Nov;4(6):500–509. doi: 10.1203/00006450-197011000-00002. [DOI] [PubMed] [Google Scholar]
  16. Neter E. The immune response of the host: an aid to etiology, pathogenesis, diagnosis, and epidemiology of bacterial infections. Yale J Biol Med. 1971 Dec;44(3):241–246. [PMC free article] [PubMed] [Google Scholar]
  17. Solowey A. C., Rapaport F. T. Immunologic responses in cancer patients. Surg Gynecol Obstet. 1965 Oct;121(4):756–760. [PubMed] [Google Scholar]
  18. Tanapatchaiyapong P., Zolla S. Humoral immunosuppressive substance in mice bearing plasmacytomas. Science. 1974 Nov 22;186(4165):748–750. doi: 10.1126/science.186.4165.748. [DOI] [PubMed] [Google Scholar]
  19. Umsawasdi T., Middleman E. A., Luna M., Bodey G. P. Klebsiella bacteremia in cancer patients. Am J Med Sci. 1973 Jun;265(6):473–482. doi: 10.1097/00000441-197306000-00006. [DOI] [PubMed] [Google Scholar]
  20. Zolla S., Naor D., Tanapatchaiyapong P. Cellular basis of immunodepression in mice with plasmacytomas. J Immunol. 1974 Jun;112(6):2068–2076. [PubMed] [Google Scholar]

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