Abstract
Rocky Mountain spotted fever vaccine was produced from rickettsiae grown in chicken embryo cells in roller bottle cultures. The rickettsiae were concentrated and purified by passage through a sucrose gradient and inactivated with formalin. This vaccine satisfactorily passed preinactivation and final container testing and is believed to be superior to the presently available yolk sac vaccine.
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Selected References
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- Calia F. M., Bartelloni P. J., McKinney R. W. Rocky Mountain spotted fever. Laboratory infection in a vaccinated individual. JAMA. 1970 Mar 23;211(12):2012–2014. [PubMed] [Google Scholar]
- DuPont H. L., Hornick R. B., Dawkins A. T., Heiner G. G., Fabrikant I. B., Wisseman C. L., Jr, Woodward T. E. Rocky Mountain spotted fever: a comparative study of the active immunity induced by inactivated and viable pathogenic Rickettsia rickettsii. J Infect Dis. 1973 Sep;128(3):340–344. doi: 10.1093/infdis/128.3.340. [DOI] [PubMed] [Google Scholar]
- JACKSON E. B., SMADEL J. E. Immunization against scrub typhus. II. Preparation of lyophilized living vaccine. Am J Hyg. 1951 May;53(3):326–331. doi: 10.1093/oxfordjournals.aje.a119457. [DOI] [PubMed] [Google Scholar]
- Johnson J. E., 3rd, Kadull P. J. Rocky Mountain spotted fever acquired in a laboratory. N Engl J Med. 1967 Oct 19;277(16):842–847. doi: 10.1056/NEJM196710192771603. [DOI] [PubMed] [Google Scholar]
- Kenyon R. H., Acree W. M., Wright G. G., Melchior F. W., Jr Preparation of vaccines for Rocky Mountain spotted fever from rickettsiae propagated in cell culture. J Infect Dis. 1972 Feb;125(2):146–152. doi: 10.1093/infdis/125.2.146. [DOI] [PubMed] [Google Scholar]
- LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
- Public Health Weekly Reports for OCTOBER 9, 1925. Public Health Rep. 1925 Oct 9;40(41):2159–2208. [PMC free article] [PubMed] [Google Scholar]
- SHELOKOV A., VOGEL J. E., CHI L. Hemadsorption (adsorption-hemagglutination) test for viral agents in tissue culture with special reference to influenza. Proc Soc Exp Biol Med. 1958 Apr;97(4):802–809. doi: 10.3181/00379727-97-23884. [DOI] [PubMed] [Google Scholar]
- Silberman R., Fiset P. Method for counting Rickettsiae and Chlamydiae in purified suspensions. J Bacteriol. 1968 Jan;95(1):259–261. doi: 10.1128/jb.95.1.259-261.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WOODWARD T. E. Rickettsial diseases in the United States. Med Clin North Am. 1959 Sep;43:1507–1535. doi: 10.1016/s0025-7125(16)34109-8. [DOI] [PubMed] [Google Scholar]