Abstract
Rosenkranz, Herbert S. (Columbia University, New York, N.Y.), and Howard S. Carr. Studies with hydroxyurea. II. Prolonged exposure of Escherichia coli to hydroxyurea. J. Bacteriol. 92:178–185. 1966.—Concurrent with an inhibition of the synthesis of deoxyribonucleic acid, hydroxyurea devitalized Escherichia coli when exposure to the drug was prolonged to more than 3 hr. Active protein synthesis, but not ribonucleic acid (RNA) production, was a prerequisite for this lethal action. These findings are contrasted to thymineless death, which requires RNA synthesis.
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Selected References
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