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. 1966 Oct;92(4):1150–1153. doi: 10.1128/jb.92.4.1150-1153.1966

Cytotoxic Effects In Vitro of Highly Purified Streptolysin O on Mouse Macrophages Cultured in a Serum-Free Medium

Robert M Fauve a,1, Joseph E Alouf a,2,3, Albert Delaunay a,1, Marcel Raynaud a,2
PMCID: PMC276390  PMID: 5926743

Abstract

Fauve, Robert M. (Institut Pasteur, Garches (Hauts de Seine), France), Joseph E. Alouf, Albert Delaunay, and Marcel Raynaud. Cytotoxic effects in vitro of highly purified streptolysin O on mouse macrophages cultured in a serum-free medium. J. Bacteriol. 92:1150–1153. 1966.—After the addition of highly purified streptolysin O to mouse macrophages cultured in medium 199 containing albumin, the following cellular alterations were observed. The disappearance of the stellate shape of the cells and the formation of bleb-like vesicles extruding from the cytoplasmic membrane occurred within a few minutes. Later, massive degranulation and formation of cytoplasmic vesicles were followed by cell death.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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