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. 1967 Feb;93(2):538–543. doi: 10.1128/jb.93.2.538-543.1967

Mechanisms of Pathogenesis in Listeria monocytogenes Infection III. Carbohydrate Metabolism

Martin S Wilder a,1, C P Sword a
PMCID: PMC276473  PMID: 4289850

Abstract

Several enzymes and metabolites concerned with carbohydrate metabolism were examined in mice infected with Listeria monocytogenes. Liver glycogen and glucose decreased parallel to severity of infection. The concentration of glucose in the blood fell to abnormally low levels with a hypoglycemia being most evident at 72 hr. There was a significant decrease in the activity of hepatic uridine diphosphate glucose-glycogen transglucosylase. This decrease in enzymatic activity correlated with the rate of glycogen depletion. Phosphorylase activity declined in a similar fashion, contraindicating enhanced glycogenolysis as the mechanism responsible for glycogen depletion. Although glucose-6-phosphatase decreased throughout the infection period, it did not appear to be the major metabolic defect causing hypoglycemia in Listeria-infected mice. Further distortion of carbohydrate metabolism was indicated by findings of increased levels of pyruvate and lactate in the blood of infected animals.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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