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. 1967 Mar;93(3):773–778. doi: 10.1128/jb.93.3.773-778.1967

Early Antibody Response in Mice to Either Infection or Immunization with Salmonella typhimurium

Kathryn Kenny 1, Mendel Herzberg 1
PMCID: PMC276515  PMID: 5337833

Abstract

After immunization with either live or heat-killed Salmonella typhimurium, mice responded with an extremely rapid production of bactericidal antibody which was correlated with the appearance of immunity to a heavy challenge dose (100 ld50) of the virulent bacteria. Inactivation of sera with mercaptoethanol along with Sephadex fractionation indicated that the observed bactericidal activity was associated with a macroglobulin which was completely mercaptoethanol-sensitive. The unexpected finding, that a heat-killed vaccine gave excellent protection from a challenge dose which killed all unimmunized control mice, seriously challenges the theory attributing immunity against typhoid infection entirely to a cellular host factor produced only in response to a live vaccine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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