Abstract
Growth of Escherichia coli E-26 on valeric acid results in the formation of a mutant population characterized by the ability to form constitutively several glyoxylate-condensing enzymes. This mutant also differs from the parent organism in the ability to effect rapid growth on a series of short-chain fatty acids. These mutants were utilized in postulating genetic relationships among the various glyoxylate-condensing activities and also in correlating the presence of these enzymes with the ability of the mutants to initiate growth quickly on short-chain fatty acids.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- KORNBERG H. L., MADSEN N. B. Synthesis of C4-dicarboxylic acids from acetate by a glyoxylate bypass of the tricarboxylic acid cycle. Biochim Biophys Acta. 1957 Jun;24(3):651–653. doi: 10.1016/0006-3002(57)90268-8. [DOI] [PubMed] [Google Scholar]
- Luria S. E., Delbrück M. Mutations of Bacteria from Virus Sensitivity to Virus Resistance. Genetics. 1943 Nov;28(6):491–511. doi: 10.1093/genetics/28.6.491. [DOI] [PMC free article] [PubMed] [Google Scholar]
- REEVES H. C., AJL S. Occurrence and function of isocitritase and malate synthetase in bacteria. J Bacteriol. 1960 Mar;79:341–345. doi: 10.1128/jb.79.3.341-345.1960. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rabin R., Reeves H. C., Wegener W. S., Megraw R. E., Ajl S. J. Glyoxylate in fatty-acid metabolism. Science. 1965 Dec 17;150(3703):1548–1558. doi: 10.1126/science.150.3703.1548. [DOI] [PubMed] [Google Scholar]
- VANDERWINKEL E., LIARD P., RAMOS F., WIAME J. M. Genetic control of the regulation of isocitritase and malate synthase in Escherichia coli K 12. Biochem Biophys Res Commun. 1963 Jul 18;12:157–162. doi: 10.1016/0006-291x(63)90254-7. [DOI] [PubMed] [Google Scholar]
- WEGENER W. S., REEVES H. C., AJL S. J. AN ISOTOPIC METHOD FOR ASSAYING THE CONDENSATION OF GLYOXYLATE WITH ACETYL-COA AND OTHER SHORT-CHAIN FATTY ACID ACYL-COA DERIVATIVES. Anal Biochem. 1965 Apr;11:111–120. doi: 10.1016/0003-2697(65)90049-7. [DOI] [PubMed] [Google Scholar]
- Wegener W. S., Reeves H. C., Ajl S. J. Heterogeneity of the Glyoxylate-Condensing Enzymes. J Bacteriol. 1965 Sep;90(3):594–598. doi: 10.1128/jb.90.3.594-598.1965. [DOI] [PMC free article] [PubMed] [Google Scholar]