Abstract
The distribution of platinum ions within Escherichia coli after the induction of filaments with cis-Pt(NH3)2Cl4, and after growth inhibition by PtCl62−, has been determined with radioactive metal compounds (191Pt, with a half-life of approximately 3 days) by the simple chemical procedure of Roberts et al. In the filamentous cells, the platinum metal is associated with metabolic intermediates, nucleic acids, and cytoplasmic proteins; whereas, in inhibited cells, the platinum is combined only with the cytoplasmic protein. Similar experiments with gram-positive cells of Bacillus cereus and Staphyloccus aureus, which show no filamentous growth in the presence of cis-Pt(NH3)2Cl4, reveal that the metal complex does penetrate the cell wall and subsequently becomes bound predominantly by metabolic intermediates.
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Selected References
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