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. 1969 Feb;62(2):597–603. doi: 10.1073/pnas.62.2.597

DEOXYRIBONUCLEASE IV: A NEW EXONUCLEASE FROM MAMMALIAN TISSUES*

Tomas Lindahl 1,†, Joseph A Gally 1, Gerald M Edelman 1
PMCID: PMC277851  PMID: 5256235

Abstract

An exonuclease which specifically degrades double-standard DNA has been isolated from rabbit tissues. The enzyme has an approximate molecular weight of 42,000, requires a divalent metal ion as cofactor, and attacks DNA at the 5′-terminal ends, thereby liberating 5′-mononucleotides. It degrades several synthetic polydeoxynucleotides of single repeating base sequences more rapidly than DNA from natural sources. The specificity of this mammalian enzyme resembles that of several microbial enzymes (phage λ exonuclease and DNA polymerase) which appear to be required for repair and recombination of DNA.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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