Skip to main content
PMC home page
Journal of Bacteriology logoLink to Journal of Bacteriology
. 1963 May;85(5):1032–1038. doi: 10.1128/jb.85.5.1032-1038.1963

DUAL NATURE OF RESISTANCE MECHANISMS AS REVEALED BY STUDIES OF ANTHRAX SEPTICEMIA1

Frederick Klein a, Bertram W Haines a, Bill G Mahlandt a, Ira A DeArmon Jr a,2, Ralph E Lincoln a
PMCID: PMC278280  PMID: 14043991

Abstract

Klein, Frederick (Fort Detrick, Frederick, Md.), Bertram W. Haines, Bill G. Mahlandt, Ira A. DeArmon, Jr., and Ralph E. Lincoln. Dual nature of resistance mechanisms as revealed by studies of anthrax septicemia. J. Bacteriol. 85:1032–1038. 1963.—From studies of septicemic anthrax, resistance was described in relation to toxin and to growth of bacilli. This description was based on the observations that the terminal concentrations of bacilli in the blood were influenced primarily by the susceptibility of the host to toxin, whereas the death-response time of the host was dependent on both resistance to bacilli and toxin susceptibility. Resistance to the establishment and growth of infecting organisms and susceptibility to the toxin produced by growth of the bacilli are separate aspects of pathogenesis. A complete description of pathogenesis must accordingly treat of both these phenomena as individual entities.

Full text

PDF
1038

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALBRINK W. S., GOODLOW R. J. Experimental inhalation anthrax in the chimpanzee. Am J Pathol. 1959 Sep-Oct;35:1055–1065. [PMC free article] [PubMed] [Google Scholar]
  2. BENNETT I. L., Jr, BEESON P. B. Bacteremia: a consideration of some experimental and clinical aspects. Yale J Biol Med. 1954 Feb;26(4):241–262. [PMC free article] [PubMed] [Google Scholar]
  3. KEPPIE J., SMITH H., HARRIS-SMITH P. W. The chemical basis of the virulence of Bacillus anthracis. III. The role of the terminal bacteraemia in death of guinea-pigs from anthrax. Br J Exp Pathol. 1955 Jun;36(3):315–322. [PMC free article] [PubMed] [Google Scholar]
  4. KLEIN F., HODGES D. R., MAHLANDT B. G., JONES W. I., HAINES B. W., LINCOLN R. E. Anthrax toxin: causative agent in the death of rhesus monkeys. Science. 1962 Dec 21;138(3547):1331–1333. doi: 10.1126/science.138.3547.1331. [DOI] [PubMed] [Google Scholar]
  5. KLEIN F., MAHLANDT B. G., LINCOLN R. E., DEARMON I. A., Jr, FERNELIUS A. L. Immunization as a factor affecting the course of septicemic anthrax. Science. 1961 Mar 31;133(3457):1021–1022. doi: 10.1126/science.133.3457.1021. [DOI] [PubMed] [Google Scholar]
  6. MIDDLETON G. K., STANDEN A. C. The electrocardiogram in fatal anthrax bacteremia. J Infect Dis. 1961 Jan-Feb;108:85–89. doi: 10.1093/infdis/108.1.85. [DOI] [PubMed] [Google Scholar]
  7. SMITH H., KEPPIE J., STANLEY J. L. The chemical basis of the virulence of Bacillus anthracis. V. The specific toxin produced by B. Anthracis in vivo. Br J Exp Pathol. 1955 Oct;36(5):460–472. [PMC free article] [PubMed] [Google Scholar]
  8. STANLEY J. L., SMITH H. Purification of factor I and recognition of a third factor of the anthrax toxin. J Gen Microbiol. 1961 Sep;26:49–63. doi: 10.1099/00221287-26-1-49. [DOI] [PubMed] [Google Scholar]
  9. TAYLOR M. J., KENNEDY G. H., BUNDELL G. P. Experimental anthrax in the rat. I. The rapid increase of natural resistance observed in young hosts. Am J Pathol. 1961 Apr;38:469–480. [PMC free article] [PubMed] [Google Scholar]
  10. THORNE C. B., MOLNAR D. M., STRANGE R. E. Production of toxin in vitro by Bacillus anthracis and its spearation into two components. J Bacteriol. 1960 Mar;79:450–455. doi: 10.1128/jb.79.3.450-455.1960. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Bacteriology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES