Skip to main content
Journal of Bacteriology logoLink to Journal of Bacteriology
. 1963 Nov;86(5):1084–1097. doi: 10.1128/jb.86.5.1084-1097.1963

SEROLOGY OF THE SOLUBLE ANTIGENS OF THE PATHOGENIC CLOSTRIDIA

Paul D Ellner a,1, Stanley S Green a
PMCID: PMC278570  PMID: 14080776

Abstract

Ellner, Paul D. (University of Vermont, Burlington), and Stanley S. Green. Serology of the soluble antigens of the pathogenic clostridia. J. Bacteriol. 86:1084–1097. 1963.—Soluble antigens of 42 strains, representing nine species of clostridia commonly occurring in human infections, were prepared by growing the organisms in a nonantigenic medium. Serological studies demonstrated the occurrence of considerable strain variation within each species. Interactions among the nine species, as well as with the previously characterized Clostridium perfringens, were also investigated. Extreme heterogeneity was observed among the species studied, with many cross-reactions due to common antigens, although species-specific antigens were also found in some cases. Occasional weak reactions were also demonstrated between certain clostridial antisera and the soluble antigens of three of the four species of Bacillus studied.

Full text

PDF
1088

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BJORKLUND B., BERENGO A. Studies on the antigenic composition of some clostridia toxins with the aid of gel diffusion. Acta Pathol Microbiol Scand. 1954;34(1):79–86. doi: 10.1111/j.1699-0463.1954.tb00803.x. [DOI] [PubMed] [Google Scholar]
  2. BROOKS M. E., EPPS H. B. Taxonomic studies of the genus Clostridium: Clostrididum bifermentans and C. sordellii. J Gen Microbiol. 1959 Aug;21:144–155. doi: 10.1099/00221287-21-1-144. [DOI] [PubMed] [Google Scholar]
  3. Duffett N. D. The Differentiation of Bacillus fallax (Weinberg and Séguin) from Bacillus carnis (Klein). J Bacteriol. 1935 Jun;29(6):573–581. doi: 10.1128/jb.29.6.573-581.1935. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. ELLNER P. D., BOHAN C. D. Serology of the soluble antigens of Clostridium perfringens types A-F by agar-gel diffusion. J Bacteriol. 1962 Feb;83:284–296. doi: 10.1128/jb.83.2.284-296.1962. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. ELLNER P. D., GREEN S. S. SEROLOGICAL GROUPING OF THE PATHOGENIC CLOSTRIDIA. J Bacteriol. 1963 Nov;86:1098–1100. doi: 10.1128/jb.86.5.1098-1100.1963. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. FULTHORPE A. J., THOMSON R. O. Antigenic efficiency of tetanus toxoids modified by excess formalin or by heat and phenol. Immunology. 1960 Apr;3:126–134. [PMC free article] [PubMed] [Google Scholar]
  7. HOWARD J. G. The haemolysin of Clostridium histolyticum. Br J Exp Pathol. 1953 Oct;34(5):564–567. [PMC free article] [PubMed] [Google Scholar]
  8. KAUFMAN L., WEAVER R. H. Rapid methods for the identification of clostridia. J Bacteriol. 1960 Jan;79:119–121. doi: 10.1128/jb.79.1.119-121.1960. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. MACLENNAN J. D. The histotoxic clostridial infections of man. Bacteriol Rev. 1962 Jun;26:177–276. [PMC free article] [PubMed] [Google Scholar]
  10. MANDIA J. W., BRUNER D. W. The serological identification of cultures of Clostridium sporogenes. J Immunol. 1951 May;66(5):497–505. [PubMed] [Google Scholar]
  11. MANDIA J. W. The serological identification of cultures of Clostridium histolyticum as group III of the proteolytic Clostridia. J Infect Dis. 1952 Jan-Feb;90(1):48–50. doi: 10.1093/infdis/90.1.48. [DOI] [PubMed] [Google Scholar]
  12. MILES E. M., MILES A. A. The relation of toxicity and enzyme activity in the lecithinases of clostridium bifermentans and clostridium welchii. J Gen Microbiol. 1950 Jan;4(1):22–35. doi: 10.1099/00221287-4-1-22. [DOI] [PubMed] [Google Scholar]
  13. McCoy E., McClung L. S. SEROLOGICAL RELATIONS AMONG SPORE-FORMING ANAEROBIC BACTERIA. Bacteriol Rev. 1938 Jun;2(1):47–97. doi: 10.1128/br.2.1.47-97.1938. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Smith L. Some Serological Aspects of the S-R Change in Clostridium histolyticum. J Bacteriol. 1937 Oct;34(4):409–417. doi: 10.1128/jb.34.4.409-417.1937. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Spray R. S. Semisolid Media for Cultivation and Identification of Sporulating Anaerobes. J Bacteriol. 1936 Aug;32(2):135–155. doi: 10.1128/jb.32.2.135-155.1936. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. WALKER P. D. The spore antigens of Clostridium sporogenes, Cl. bifermentans and Cl. sordellii. J Pathol Bacteriol. 1963 Jan;85:41–49. doi: 10.1002/path.1700850105. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Bacteriology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES