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. 1961 Aug;82(2):169–180. doi: 10.1128/jb.82.2.169-180.1961

EFFECTS OF DEOXYRIBONUCLEIC ACID PRODUCTS ON DEOXYRIBONUCLEIC ACID SYNTHESIS OF VIRULENT AND AVIRULENT PNEUMOCOCCI

W Firshein 1
PMCID: PMC279139  PMID: 13699770

Abstract

Firshein, W. (Wesleyan University, Middletown, Conn.). Effects of deoxyribonucleic acid products on deoxyribonucleic acid synthesis of virulent and avirulent pneumococci. J. Bacteriol. 82:169–180. 1961.—Cell suspensions of virulent pneumococci synthesize a greater amount of deoxyribonucleic acid (DNA) per cell in the presence of DNA + deoxyribonuclease + mixtures of deoxynucleosides and deoxynucleotides (supplement-1) than unsupplemented suspensions. Under identical conditions, avirulent and weakly virulent pneumococci do not respond to these DNA breakdown products. Glucose and casitone must be present for maximal effects to occur.

A DNA turnover occurs in virulent cells. This has been demonstrated by a decrease in specific activity of H3-DNA extracted from virulent (S) cells exposed to nonradioactive supplement-1.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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