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. 1993 Aug;61(8):3540–3543. doi: 10.1128/iai.61.8.3540-3543.1993

Protection against murine disseminated candidiasis mediated by a Candida albicans-specific T-cell line.

T G Sieck 1, M A Moors 1, H R Buckley 1, K J Blank 1
PMCID: PMC281036  PMID: 8335385

Abstract

The role of T lymphocytes in disseminated candidiasis in a mouse model of irradiation-induced immunosuppression was investigated. A continuously cultured Candida albicans-specific T-cell line mediated protection of sublethally irradiated mice from disseminated candidiasis as measured by both the fungal load in the kidneys and mortality. These results are the first to demonstrate directly a role for antigen-specific T cells in the protective immune response against murine disseminated candidiasis.

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Selected References

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  1. Ashman R. B. Mouse candidiasis. II. Host responses are T-cell dependent and regulated by genes in the major histocompatibility complex. Immunogenetics. 1987;25(3):200–203. doi: 10.1007/BF00344035. [DOI] [PubMed] [Google Scholar]
  2. Baghian A., Lee K. W. Systemic candidosis in beige mice. J Med Vet Mycol. 1989;27(1):51–55. doi: 10.1080/02681218980000071. [DOI] [PubMed] [Google Scholar]
  3. Bodey G. P. Candidiasis in cancer patients. Am J Med. 1984 Oct 30;77(4D):13–19. [PubMed] [Google Scholar]
  4. Borish L., Rosenbaum R., Albury L., Clark S. Activation of neutrophils by recombinant interleukin 6. Cell Immunol. 1989 Jul;121(2):280–289. doi: 10.1016/0008-8749(89)90026-9. [DOI] [PubMed] [Google Scholar]
  5. Cantorna M. T., Balish E. Mucosal and systemic candidiasis in congenitally immunodeficient mice. Infect Immun. 1990 Apr;58(4):1093–1100. doi: 10.1128/iai.58.4.1093-1100.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Cantorna M. T., Balish E. Role of CD4+ lymphocytes in resistance to mucosal candidiasis. Infect Immun. 1991 Jul;59(7):2447–2455. doi: 10.1128/iai.59.7.2447-2455.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Cohen M. S., Isturiz R. E., Malech H. L., Root R. K., Wilfert C. M., Gutman L., Buckley R. H. Fungal infection in chronic granulomatous disease. The importance of the phagocyte in defense against fungi. Am J Med. 1981 Jul;71(1):59–66. doi: 10.1016/0002-9343(81)90259-x. [DOI] [PubMed] [Google Scholar]
  8. Cutler J. E. Acute systemic candidiasis in normal and congenitally thymic-deficient (nude) mice. J Reticuloendothel Soc. 1976 Feb;19(2):121–124. [PubMed] [Google Scholar]
  9. DIXON F. J., TALMAGE D. W., MAURER P. H. Radiosensitive and radioresistant phases in the antibody response. J Immunol. 1952 Jun;68(6):693–700. [PubMed] [Google Scholar]
  10. Djeu J. Y., Blanchard D. K., Halkias D., Friedman H. Growth inhibition of Candida albicans by human polymorphonuclear neutrophils: activation by interferon-gamma and tumor necrosis factor. J Immunol. 1986 Nov 1;137(9):2980–2984. [PubMed] [Google Scholar]
  11. Greenfield R. A. Host defense system interactions with Candida. J Med Vet Mycol. 1992;30(2):89–104. [PubMed] [Google Scholar]
  12. Holmberg K., Meyer R. D. Fungal infections in patients with AIDS and AIDS-related complex. Scand J Infect Dis. 1986;18(3):179–192. doi: 10.3109/00365548609032326. [DOI] [PubMed] [Google Scholar]
  13. Inoue T., Sendo F. In vitro induction of cytotoxic polymorphonuclear leukocytes by supernatant from a concanavalin A-stimulated spleen cell culture. J Immunol. 1983 Nov;131(5):2508–2514. [PubMed] [Google Scholar]
  14. Lehrer R. I., Cline M. J. Leukocyte myeloperoxidase deficiency and disseminated candidiasis: the role of myeloperoxidase in resistance to Candida infection. J Clin Invest. 1969 Aug;48(8):1478–1488. doi: 10.1172/JCI106114. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Mahanty S., Greenfield R. A., Joyce W. A., Kincade P. W. Inoculation candidiasis in a murine model of severe combined immunodeficiency syndrome. Infect Immun. 1988 Dec;56(12):3162–3166. doi: 10.1128/iai.56.12.3162-3166.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Miyake T., Takeya K., Nomoto K., Muraoka S. Cellular elements in the resistance to candida infection in mice. I. Contribution of T lymphocytes and phagocytes at various stages of infection. Microbiol Immunol. 1977;21(12):703–725. doi: 10.1111/j.1348-0421.1977.tb00339.x. [DOI] [PubMed] [Google Scholar]
  17. Moors M. A., Jones S. M., Klyczek K. K., Rogers T. J., Buckley H. R., Blank K. J. Effect of Friend leukemia virus infection on susceptibility to Candida albicans. Infect Immun. 1990 Jun;58(6):1796–1801. doi: 10.1128/iai.58.6.1796-1801.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Narayanan R., Joyce W. A., Greenfield R. A. Gastrointestinal candidiasis in a murine model of severe combined immunodeficiency syndrome. Infect Immun. 1991 Jun;59(6):2116–2119. doi: 10.1128/iai.59.6.2116-2119.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Rogers T. J., Balish E., Manning D. D. The role of thymus-dependent cell-mediated immunity in resistance to experimental disseminated candidiasis. J Reticuloendothel Soc. 1976 Oct;20(4):291–298. [PubMed] [Google Scholar]
  20. Rogers T. J., Balish E. The role of activated macrophages in resistance to experimental renal candidiasis. J Reticuloendothel Soc. 1977 Oct;22(4):309–318. [PubMed] [Google Scholar]
  21. Rogers T., Balish E. Experimental Candida albicans infection in conventional mice and germfree rats. Infect Immun. 1976 Jul;14(1):33–38. doi: 10.1128/iai.14.1.33-38.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Romani L., Mencacci A., Grohmann U., Mocci S., Mosci P., Puccetti P., Bistoni F. Neutralizing antibody to interleukin 4 induces systemic protection and T helper type 1-associated immunity in murine candidiasis. J Exp Med. 1992 Jul 1;176(1):19–25. doi: 10.1084/jem.176.1.19. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Shalaby M. R., Aggarwal B. B., Rinderknecht E., Svedersky L. P., Finkle B. S., Palladino M. A., Jr Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors. J Immunol. 1985 Sep;135(3):2069–2073. [PubMed] [Google Scholar]
  24. Sobel J. D. Candida infections in the intensive care unit. Crit Care Clin. 1988 Apr;4(2):325–344. [PubMed] [Google Scholar]
  25. Street N. E., Mosmann T. R. Functional diversity of T lymphocytes due to secretion of different cytokine patterns. FASEB J. 1991 Feb;5(2):171–177. doi: 10.1096/fasebj.5.2.1825981. [DOI] [PubMed] [Google Scholar]
  26. Strockbine N. A., Largen M. T., Zweibel S. M., Buckley H. R. Identification and molecular weight characterization of antigens from Candida albicans that are recognized by human sera. Infect Immun. 1984 Feb;43(2):715–721. doi: 10.1128/iai.43.2.715-721.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Valdimarsson H., Higgs J. M., Wells R. S., Yamamura M., Hobbs J. R., Holt P. J. Immune abnormalities associated with chronic mucocutaneous candidiasis. Cell Immunol. 1973 Mar;6(3):348–361. doi: 10.1016/0008-8749(73)90035-x. [DOI] [PubMed] [Google Scholar]
  28. Weisbart R. H., Golde D. W., Clark S. C., Wong G. G., Gasson J. C. Human granulocyte-macrophage colony-stimulating factor is a neutrophil activator. 1985 Mar 28-Apr 3Nature. 314(6009):361–363. doi: 10.1038/314361a0. [DOI] [PubMed] [Google Scholar]

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