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. 1993 Aug;61(8):3540–3543. doi: 10.1128/iai.61.8.3540-3543.1993

Protection against murine disseminated candidiasis mediated by a Candida albicans-specific T-cell line.

T G Sieck 1, M A Moors 1, H R Buckley 1, K J Blank 1
PMCID: PMC281036  PMID: 8335385

Abstract

The role of T lymphocytes in disseminated candidiasis in a mouse model of irradiation-induced immunosuppression was investigated. A continuously cultured Candida albicans-specific T-cell line mediated protection of sublethally irradiated mice from disseminated candidiasis as measured by both the fungal load in the kidneys and mortality. These results are the first to demonstrate directly a role for antigen-specific T cells in the protective immune response against murine disseminated candidiasis.

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Selected References

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