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. 1993 Sep;61(9):3988–3993. doi: 10.1128/iai.61.9.3988-3993.1993

Clostridium difficile toxin A elicits Ca(2+)-independent cytotoxic effects in cultured normal rat intestinal crypt cells.

C Fiorentini 1, G Donelli 1, P Nicotera 1, M Thelestam 1
PMCID: PMC281105  PMID: 8359922

Abstract

In rat intestinal crypt cells, Clostridium difficile toxin A induces (i) early cytoskeletal alterations involving the whole population and (ii) late effects in 30 to 40% of the cells, consisting mainly of surface blebbing and nuclear fragmentation. All these effects were Ca2+ independent and were not abolished by protein synthesis inhibitors.

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Selected References

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