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. 1993 Nov;61(11):4929–4932. doi: 10.1128/iai.61.11.4929-4932.1993

Failure of pulmonary clearance of Rhodococcus equi infection in CD4+ T-lymphocyte-deficient transgenic mice.

S T Kanaly 1, S A Hines 1, G H Palmer 1
PMCID: PMC281259  PMID: 8104903

Abstract

Pulmonary clearance of Rhodococcus equi requires functional T lymphocytes. In this study, CD8+ T-lymphocyte-deficient transgenic mice cleared virulent R. equi from the lungs while infection in CD4+ T-lymphocyte-deficient transgenic mice persisted. Although both CD4+ and CD8+ T cells function early in pulmonary defense against R. equi, clearance is dependent on CD4+ T lymphocytes.

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Selected References

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