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. 1993 Nov;61(11):4937–4939. doi: 10.1128/iai.61.11.4937-4939.1993

Interleukin 10 protects mice against staphylococcal enterotoxin B-induced lethal shock.

A G Bean 1, R A Freiberg 1, S Andrade 1, S Menon 1, A Zlotnik 1
PMCID: PMC281261  PMID: 8406900

Abstract

We investigated the ability of interleukin 10 (IL-10) to protect mice against lethal shock induced by staphylococcal enterotoxin B (SEB). Treatment of mice with IL-10 prevented the death of mice injected with SEB in a dose-dependent manner. IL-10-mediated protection was apparent when administered either prior to or concurrent with SEB but was less effective when administered following SEB injection. This observation indicates that IL-10 is capable of regulating T-cell activation in vivo.

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Selected References

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