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. 1993 Apr;61(4):1378–1384. doi: 10.1128/iai.61.4.1378-1384.1993

Association between expression of immunoglobulin G-binding proteins by group A streptococci and virulence in a mouse skin infection model.

R Raeder 1, M D Boyle 1
PMCID: PMC281374  PMID: 8454339

Abstract

In this study, we developed a mouse model of skin infection to test the association between expression of immunoglobulin-binding proteins by and infectivity of group A streptococci. Group A streptococci capable of crossing tissue barriers and establishing a lethal systemic infection in mice showed a higher level of immunoglobulin-binding protein expression. The group A streptococci recovered from the spleen of a mouse that died following a skin infection were found to be more virulent when injected into the skin of naive mice. Together, these results suggest that immunoglobulin-binding protein expression by group A streptococci correlates with their ability to establish invasive skin infections.

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Selected References

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