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. 1988 Jul;85(14):5220–5223. doi: 10.1073/pnas.85.14.5220

Direct evidence for functional self-protein/Ia-molecule complexes in vivo.

R G Lorenz 1, P M Allen 1
PMCID: PMC281720  PMID: 2839836

Abstract

Through the development of a panel of murine hybridomas reactive to murine hemoglobin, we have been able to study the processing and presentation of self antigens by antigen-presenting cells. Our results demonstrate that peritoneal macrophages in vivo can process and potentially present the self-antigen hemoglobin. We have extended this finding to show that, directly after removal from the mouse, antigen-presenting cells from a variety of tissues stimulate our hemoglobin-specific hybridomas without any manipulation or addition of exogenous antigen. This constitutes direct functional proof that in a nondisease state self proteins are processed constitutively and can be presented in a fashion similar to that in which foreign antigens are presented. Our demonstration that antigen-presenting cells can process and potentially present self as well as foreign molecules implies that self-tolerance occurs at the level of the T cell. This constitutive processing and presentation of self antigens has potentially far-reaching implications in self-tolerance, autoimmunity, and alloreactivity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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