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. 1988 Aug;85(15):5483–5487. doi: 10.1073/pnas.85.15.5483

Antibodies in human serum that precipitate ribonuclease P.

H A Gold 1, J Craft 1, J A Hardin 1, M Bartkiewicz 1, S Altman 1
PMCID: PMC281781  PMID: 2456570

Abstract

Sera from certain patients with systemic lupus erythematosus (SLE) and related rheumatic diseases contain antibodies that selectively deplete extracts of HeLa cells of RNase P activity. Most of the sera that recognize RNase P, an endoribonuclease with an essential RNA subunit, also contain antibodies against another small ribonucleoprotein known as the Th antigen. A species of RNA about 400 nucleotides in length is the only RNA species found in common in all immunoprecipitates prepared with anti-RNase P antibodies. The discovery of antibodies against RNase P defines a major class of antibodies produced by patients with autoimmune disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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