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. 1988 Sep;85(17):6446–6449. doi: 10.1073/pnas.85.17.6446

Molecular and cytogenetic evidence for the location of Tdy and Hya on the mouse Y chromosome short arm.

C Roberts 1, A Weith 1, E Passage 1, J L Michot 1, M G Mattei 1, C E Bishop 1
PMCID: PMC281989  PMID: 3413106

Abstract

Using a combination of in situ mapping and DNA analysis with recombinant DNA probes specific for the Sxr region of the mouse Y chromosome, we show that both the gene(s) controlling sex determination and the expression of the male-specific antigen H-Y (Tdy and Hya, respectively) are located on the minute short arm of the mouse Y chromosome. We demonstrate that the H-Y- variant of Sxr (Sxr') arose by a partial deletion within the Sxr region. Also, we show that intrachromosomal recombination between the Y short arm and Sxr' can sometimes occur during male meiosis, restoring the deleted DNA sequences and resulting in an H-Y+ mouse (male 719 in this paper). Based on these results, we propose a model for the generation of the original Sxr region and the Sxr' and Sxr719 variants.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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