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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1988 Nov;85(21):8181–8185. doi: 10.1073/pnas.85.21.8181

T helper cell subsets require the expression of distinct costimulatory signals by antigen-presenting cells.

C T Weaver 1, C M Hawrylowicz 1, E R Unanue 1
PMCID: PMC282391  PMID: 2973060

Abstract

We examined the ability of macrophages and B cells to function as antigen-presenting cells (APCs) for murine TH1 and TH2 cloned T helper cell lines. Antigen presented by concanavalin A-elicited peritoneal macrophages or resting splenic B cells stimulated antigen-dependent proliferation of both T helper subsets. Paraformaldehyde fixation of the APCs following different conditions of activation indicated differential requirements for costimulatory signals by TH1 and TH2 cells. TH2 proliferative responses were strictly dependent on APC expression of IL-1. TH1 proliferation was dependent on APC expression of a non-IL-1 costimulatory signal present on freshly isolated macrophages and on splenic B cells activated with anti-immunoglobulin plus interferon gamma.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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