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. 1970 Apr;65(4):919–924. doi: 10.1073/pnas.65.4.919

Stimulation of Mammalian Erythropoiesis by 5β-H Steroid Metabolites*

Albert S Gordon 1,2,3, Esmail D Zanjani 1,2,3, Richard D Levere 1,2,3, Attallah Kappas 1,2,3
PMCID: PMC283004  PMID: 5266162

Abstract

The effects of a number of steroid compounds on erythropoiesis in normal and polycythemic mice were examined. Of the steroids that stimulated erythropoiesis, the hormone testosterone and certain 5β-H C19 and C21 nonhormonal metabolites were the most effective. Anti-erythropoietin abolished the erythropoiesis-stimulating effects of testosterone but not those exerted by the 5β-H steroid, 11-ketopregnanolone. Similarly, testosterone but not 11-ketopregnanolone evoked the production of erythropoiesis-stimulating factor in rats. It is concluded that two mechanisms underlie the stimulating actions of steroids on erythropoiesis; one through the production of erythropoietin and the second involving a more direct influence on the blood-forming tissues. The 5β-H steroid metabolites are postulated to act on erythropoiesis via the latter mechanism.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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