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. 1970 Sep;67(1):296–301. doi: 10.1073/pnas.67.1.296

Diphosphoglycerate and Inosine Hexaphosphate Control of Oxygen Binding by Hemoglobin: A Theoretical Interpretation of Experimental Data*

Gilbert N Ling 1
PMCID: PMC283202  PMID: 5272319

Abstract

A theoretical equation is presented for the control of cooperative adsorption on proteins and other linear macromolecules by hormones, drugs, ATP, and other „cardinal adsorbents.” With reasonable accuracy, this equation describes quantitatively the control of oxygen binding to hemoglobin by 2,3-diphosphoglycerate and by inosine hexaphosphate.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Benesch R., Benesch R. E. Intracellular organic phosphates as regulators of oxygen release by haemoglobin. Nature. 1969 Feb 15;221(5181):618–622. doi: 10.1038/221618a0. [DOI] [PubMed] [Google Scholar]
  2. Chanutin A., Curnish R. R. Effect of organic and inorganic phosphates on the oxygen equilibrium of human erythrocytes. Arch Biochem Biophys. 1967 Jul;121(1):96–102. doi: 10.1016/0003-9861(67)90013-6. [DOI] [PubMed] [Google Scholar]
  3. Jones A. W., Karreman G. Potassium accumulation and permeation in the canine carotid artery. Biophys J. 1969 Jul;9(7):910–924. doi: 10.1016/S0006-3495(69)86426-X. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Koshland D. E., Jr, Némethy G., Filmer D. Comparison of experimental binding data and theoretical models in proteins containing subunits. Biochemistry. 1966 Jan;5(1):365–385. doi: 10.1021/bi00865a047. [DOI] [PubMed] [Google Scholar]
  5. Ling G. N. A new model for the living cell: a summary of the theory and recent experimental evidence in its support. Int Rev Cytol. 1969;26:1–61. doi: 10.1016/s0074-7696(08)61633-2. [DOI] [PubMed] [Google Scholar]
  6. Ling G. N. All-or-none adsorption by living cells and model protein-water systems: discussion of the problem of "permease-induction" and determination of secondary and tertiary structures of proteins. Fed Proc. 1966 May-Jun;25(3):958–970. [PubMed] [Google Scholar]
  7. Ling G. N., Bohr G. Studies on ion distribution in living cells. II. Cooperative interaction between intracellular potassium and sodium ions. Biophys J. 1970 Jun;10(6):519–538. doi: 10.1016/S0006-3495(70)86317-2. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. MONOD J., CHANGEUX J. P., JACOB F. Allosteric proteins and cellular control systems. J Mol Biol. 1963 Apr;6:306–329. doi: 10.1016/s0022-2836(63)80091-1. [DOI] [PubMed] [Google Scholar]
  9. MONOD J., WYMAN J., CHANGEUX J. P. ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL. J Mol Biol. 1965 May;12:88–118. doi: 10.1016/s0022-2836(65)80285-6. [DOI] [PubMed] [Google Scholar]

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