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. 1970 Sep;67(1):456–463. doi: 10.1073/pnas.67.1.456

The Rolling Circle for ϕX DNA Replication, III. Synthesis of Supercoiled Duplex Rings*

David Dressler 1, John Wolfson 1
PMCID: PMC283226  PMID: 5272326

Abstract

During ϕX duplex ring synthesis, the first supercoils to acquire radioactivity after the addition of tritiated thymidine are labeled only in their negative strands. In longer pulses, this asymmetry of labeling progressively disappears. This finding supports the rolling circle model for DNA replication due to the structural asymmetry of its replicating intermediate, but is not predicted by the Cairns or Yoshikawa models.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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