Abstract
δ-Aminolevulinic acid synthetase is induced in chick embryo liver culture by the natural steroid, etiocholanolone, and by the foreign chemical, 3,5-dicarbethoxy-1,4-dihydrocollidine at the level of transcription. Alternatively, inducing chemicals such as allylisopropylacetamide and γ-hexachloro-cyclohexane act primarily at the level of translation. Hemin (Ki = 5 μM) inhibits the induction at the level of translation. In liver cell culture, the half-life of δ-aminolevulinic acid synthetase is 3 hr, that of mRNA about 5 hr.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Dube S. K., Rudland P. S. Control of translation by T4 phage: altered binding of disfavoured messengers. Nature. 1970 May 30;226(5248):820–823. doi: 10.1038/226820a0. [DOI] [PubMed] [Google Scholar]
- Ganschow R. E., Schimke R. T. Independent genetic control of the catalytic activity and the rate of degradation of catalase in mice. J Biol Chem. 1969 Sep 10;244(17):4649–4658. [PubMed] [Google Scholar]
- Gordon A. S., Zanjani E. D., Levere R. D., Kappas A. Stimulation of mammalian erythropoiesis by 5beta-H steroid metabolites. Proc Natl Acad Sci U S A. 1970 Apr;65(4):919–924. doi: 10.1073/pnas.65.4.919. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Granick S., Kappas A. Steroid induction of porphyrin synthesis in liver cell culture. I. Structural basis and possible physiological role in the control of heme formation. J Biol Chem. 1967 Oct 25;242(20):4587–4593. [PubMed] [Google Scholar]
- Granick S. The induction in vitro of the synthesis of delta-aminolevulinic acid synthetase in chemical porphyria: a response to certain drugs, sex hormones, and foreign chemicals. J Biol Chem. 1966 Mar 25;241(6):1359–1375. [PubMed] [Google Scholar]
- Hayashi N., Yoda B., Kikuchi G. Mechanism of allylisopropylacetamide-induced increase of delta-aminolevulinate synthetase in liver mitochondria. II. Effects of hemin and bilirubin on enzyme induction. J Biochem. 1968 Apr;63(4):446–452. doi: 10.1093/oxfordjournals.jbchem.a128796. [DOI] [PubMed] [Google Scholar]
- Hayashi N., Yoda B., Kikuchi G. Mechanism of allylisopropylacetamide-induced increase of delta-aminolevulinate synthetase in liver mitochondria. IV. Accumulation of the enzyme in the soluble fraction of rat liver. Arch Biochem Biophys. 1969 Apr;131(1):83–91. doi: 10.1016/0003-9861(69)90107-6. [DOI] [PubMed] [Google Scholar]
- Kappas A., Granick S. Steroid induction of porphyrin synthesis in liver cell culture. II. The effects of heme, uridine diphosphate glucuronic acid, and inhibitors of nucleic acid and protein synthesis on the induction process. J Biol Chem. 1968 Jan 25;243(2):346–351. [PubMed] [Google Scholar]
- Levere R. D., Kappas A., Granick S. Stimulation of hemoglobin synthesis in chick blastoderms by certain 5beta androstane and 5beta pregnane steroids. Proc Natl Acad Sci U S A. 1967 Sep;58(3):985–990. doi: 10.1073/pnas.58.3.985. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Necheles T. F., Rai U. S. Studies on the control of hemoglobin synthesis: the in vitro stimulating effect of a 5-beta-H steroid metabolite on heme formation in human bone marrow cells. Blood. 1969 Sep;34(3):380–384. [PubMed] [Google Scholar]
- Tschudy D. P., Marver H. S., Collins A. A model for calculating messenger RNA half-life: short lived messenger RNA in the induction of mammalian delta-aminolevulinic acid synthetase. Biochem Biophys Res Commun. 1965 Dec 9;21(5):480–487. doi: 10.1016/0006-291x(65)90408-0. [DOI] [PubMed] [Google Scholar]