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. 1970 Oct;67(2):1042–1049. doi: 10.1073/pnas.67.2.1042

Effect of Loss of Thymidine Kinase Activity on the Tumorigenicity of Clones of SV40-Transformed Hamster Cells*

Henry Rothschild 1, Paul H Black 1
PMCID: PMC283310  PMID: 4331716

Abstract

Cells deficient in the enzyme thymidine kinase were derived from transplantable SV40-transformed hamster cells. The resultant cell lines were less transplantable when inoculated into hamsters. Tumors which did arise from such cells had prolonged latent periods and were found to contain a mixture of enzyme-containing and enzyme-deficient cells. Revertant cell lines obtained either spontaneously or after mutagenesis in vitro contained intermediate levels of thymidine kinase activity and displayed an oncogenic potential which was intermediate between the wild type and enzyme-deficient cells. It is postulated that salvage pathway enzymes may play a rate-limiting role in tumorigenesis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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