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. 1970 Nov;67(3):1454–1461. doi: 10.1073/pnas.67.3.1454

6-(p-Hydroxyphenylazo)-uracil: A Selective Inhibitor of Host DNA Replication in Phage-Infected Bacillus subtilis

Neal C Brown 1
PMCID: PMC283373  PMID: 4992015

Abstract

The azopyrimidine, 6-(p-hydroxyphenylazo)-uracil, inhibits the replication of bacterial DNA selectively, completely, and reversibly, and has no apparent effects on the metabolism of other cellular macromolecules thus far examined. The mechanism of its action has been investigated in uninfected and phage-infected Bacillus subtilis, and the compound appears to be specific for a host function. In cells infected with virulent phage the synthesis of phage DNA proceeds normally, while residual host DNA synthesis is completely blocked. The drug-sensitive host site retains its sensitivity even after partial disruption of the cell by lysozyme treatment.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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