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. 1970 Nov;67(3):1624–1630. doi: 10.1073/pnas.67.3.1624

A Specific Competitive Inhibitor of Angiotensin II

Garland R Marshall 1,2,3,*, William Vine 1,2,3,†, Philip Needleman 1,2,3,‡
PMCID: PMC283399  PMID: 4322025

Abstract

A peptide analog, [4-phenylalanine, 8-tyrosine]-angiotensin II, was prepared by solid phase peptide synthesis and its structure confirmed. The compound was found to be a potent inhibitor of angiotensin II in vitro (isolated rat uterus strips) and in vivo (rat blood pressure). The analog was found to be highly specific and did not inhibit the action of a number of other peptides and spasmogenic compounds.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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