Skip to main content
PMC home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1970 Dec;67(4):1673–1680. doi: 10.1073/pnas.67.4.1673

Differences between the Ribonucleic Acids of Transforming and Nontransforming Avian Tumor Viruses*

Peter H Duesberg 1,2,3, Peter K Vogt 1,2,3
PMCID: PMC283411  PMID: 4321342

Abstract

The 60-70S RNAs of several transforming and nontransforming avian tumor viruses have different electrophoretic mobilities. The RNA of transforming viruses contains two electrophoretically separable subunit classes: a and b. The relative concentrations of these subunits vary with the virus strain. Avian leukosis viruses and nontransforming derivatives of a sarcoma virus lack subunits of class a. It is suggested that the presence of the class a subunit is related to the transforming ability for fibroblasts of the virus.

Full text

PDF
1677

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BALUDA M. A., GOETZ I. E. Morphological conversion of cell cultures by avian myeloblastosis virus. Virology. 1961 Oct;15:185–199. doi: 10.1016/0042-6822(61)90234-3. [DOI] [PubMed] [Google Scholar]
  2. BEARD J. W. VIRAL TUMORS OF CHICKENS WITH PARTICULAR REFERENCE TO THE LEUKOSIS COMPLEX. Ann N Y Acad Sci. 1963 Nov 4;108:1057–1085. doi: 10.1111/j.1749-6632.1963.tb13436.x. [DOI] [PubMed] [Google Scholar]
  3. BONAR R. A., BEARD J. W. Virus of avian myeloblastosis. XII. Chemical constitution. J Natl Cancer Inst. 1959 Jul;23(1):183–197. [PubMed] [Google Scholar]
  4. Bader J. P., Steck T. L. Analysis of the ribonucleic acid of murine leukemia virus. J Virol. 1969 Oct;4(4):454–459. doi: 10.1128/jvi.4.4.454-459.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Bishop D. H., Claybrook J. R., Spiegelman S. Electrophoretic separation of viral nucleic acids on polyacrylamide gels. J Mol Biol. 1967 Jun 28;26(3):373–387. doi: 10.1016/0022-2836(67)90310-5. [DOI] [PubMed] [Google Scholar]
  6. Blair C. D., Duesberg P. H. Structure of Rauscher mouse leukaemia virus RNA. Nature. 1968 Oct 26;220(5165):396–399. doi: 10.1038/220396a0. [DOI] [PubMed] [Google Scholar]
  7. Bolognesi D. P., Langlois A. J., Sverak L., Bonar R. A., Beard J. W. In vitro chick embryo cell response to strain MC29 avian leukosis virus. J Virol. 1968 Jun;2(6):576–586. doi: 10.1128/jvi.2.6.576-586.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. CRAWFORD L. V., CRAWFORD E. M. The properties of Rous sarcoma virus purified by density gradient centrifugation. Virology. 1961 Feb;13:227–232. doi: 10.1016/0042-6822(61)90056-3. [DOI] [PubMed] [Google Scholar]
  9. Duesberg P. H., Cardiff R. D. Structural relationships between the RNA of mammary tumor virus and those of other RNA tumor viruses. Virology. 1968 Dec;36(4):696–700. doi: 10.1016/0042-6822(68)90206-7. [DOI] [PubMed] [Google Scholar]
  10. Duesberg P. H., Martin G. S., Vogt P. K. Glycoprotein components of avian and murine RNA tumor viruses. Virology. 1970 Aug;41(4):631–646. doi: 10.1016/0042-6822(70)90428-9. [DOI] [PubMed] [Google Scholar]
  11. Duesberg P. H. Physical properties of Rous Sarcoma Virus RNA. Proc Natl Acad Sci U S A. 1968 Aug;60(4):1511–1518. doi: 10.1073/pnas.60.4.1511. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Duesberg P. H., Robinson H. L., Robinson W. S., Huebner R. J., Turner H. C. Proteins of Rous sarcoma virus. Virology. 1968 Sep;36(1):73–86. doi: 10.1016/0042-6822(68)90118-9. [DOI] [PubMed] [Google Scholar]
  13. Duesberg P. H. The RNA of influenza virus. Proc Natl Acad Sci U S A. 1968 Mar;59(3):930–937. doi: 10.1073/pnas.59.3.930. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Duff R. G., Vogt P. K. Characteristics of two new avian tumor virus subgroups. Virology. 1969 Sep;39(1):18–30. doi: 10.1016/0042-6822(69)90344-4. [DOI] [PubMed] [Google Scholar]
  15. HANAFUSA H., HANAFUSA T., RUBIN H. ANALYSIS OF THE DEFECTIVENESS OF ROUS SARCOMA VIRUS, II. SPECIFICATION OF RSV ANTIGENICITY BY HELPER VIRUS. Proc Natl Acad Sci U S A. 1964 Jan;51:41–48. doi: 10.1073/pnas.51.1.41. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Ishizaki R., Vogt P. K. Immunological relationships among envelope antigens of avian tumor viruses. Virology. 1966 Nov;30(3):375–387. doi: 10.1016/0042-6822(66)90116-4. [DOI] [PubMed] [Google Scholar]
  17. Montagnier L., Goldé A., Vigier P. A possible subunit structure of Rous sarcoma virus RNA. J Gen Virol. 1969 Apr;4(3):449–452. doi: 10.1099/0022-1317-4-3-449. [DOI] [PubMed] [Google Scholar]
  18. Moscovici C., Moscovici M. G., Zanetti M. Transformation of chick fibroblast cultures with avian myeloblastosis virus. J Cell Physiol. 1969 Apr;73(2):105–108. doi: 10.1002/jcp.1040730203. [DOI] [PubMed] [Google Scholar]
  19. RUBIN H., TEMIN H. M. A radiological study of cell-virus interaction in the Rous sarcoma. Virology. 1959 Jan;7(1):75–91. doi: 10.1016/0042-6822(59)90178-3. [DOI] [PubMed] [Google Scholar]
  20. Robinson W. S., Pitkanen A., Rubin H. The nucleic acid of the Bryan strain of Rous sarcoma virus: purification of the virus and isolation of the nucleic acid. Proc Natl Acad Sci U S A. 1965 Jul;54(1):137–144. doi: 10.1073/pnas.54.1.137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Rubin H. A VIRUS IN CHICK EMBRYOS WHICH INDUCES RESISTANCE IN VITRO TO INFECTION WITH ROUS SARCOMA VIRUS. Proc Natl Acad Sci U S A. 1960 Aug;46(8):1105–1119. doi: 10.1073/pnas.46.8.1105. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. THURZO V., SMIDA J., SMIDOVA-KOVAROVA V., SIMKOVIC D. Some properties of the fowl virus tumour B77. Acta Unio Int Contra Cancrum. 1963;19:304–305. [PubMed] [Google Scholar]
  23. Toyoshima K., Friis R. R., Vogt P. K. The reproductive and cell-transforming capacities of avian sarcoma virus B77: inactivation with UV light. Virology. 1970 Sep;42(1):163–170. doi: 10.1016/0042-6822(70)90249-7. [DOI] [PubMed] [Google Scholar]
  24. Vogt P. K., Ishizaki R. Reciprocal patterns of genetic resistance to avian tumor viruses in two lines of chickens. Virology. 1965 Aug;26(4):664–672. doi: 10.1016/0042-6822(65)90329-6. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES