Skip to main content
PMC home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1970 Dec;67(4):1834–1838. doi: 10.1073/pnas.67.4.1834

DNA-Induced Transformation in Drosophila: Evidence for Transmission without Integration*

Allen S Fox 1, William F Duggleby 1,†,‡, William M Gelbart 1,‡, Sei Byung Yoon 1
PMCID: PMC283436  PMID: 5275381

Abstract

A key feature of the exosome model of transformation in Drosophila melanogaster is that the DNA segments responsible for the phenomenon are not integrated into the linear structure of the chromosomes. This feature is confirmed by the failure to find whole-body transformants in a series of large-scale experiments, and by the absence of evidence for integration under conditions favoring genetic exchange between chromosomes and introduced DNA.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BECKER H. J. Uber Rontgenmosaikflecken und Defektmutationen am Auge von Drosophila und die Entwicklungsphysiologie des Auges. Z Indukt Abstamm Vererbungsl. 1957;88(3):333–373. [PubMed] [Google Scholar]
  2. Baker W. K. A clonal system of differential gene activity in Drosophila. Dev Biol. 1967 Jul;16(1):1–17. doi: 10.1016/0012-1606(67)90014-0. [DOI] [PubMed] [Google Scholar]
  3. Ehrlich E. An automatic selection procedure in Drosophila. Can J Genet Cytol. 1965 Sep;7(3):430–432. doi: 10.1139/g65-057. [DOI] [PubMed] [Google Scholar]
  4. Fox A. S., Yoon S. B. Specific genetic effects of DNA in Drosophila melanogaster. Genetics. 1966 May;53(5):897–911. doi: 10.1093/genetics/53.5.897. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Friedberg S. H., Oka T., Topper Y. J. Development of insulin-sensitivity by mouse mammary gland in vitro. Proc Natl Acad Sci U S A. 1970 Nov;67(3):1493–1500. doi: 10.1073/pnas.67.3.1493. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Ravin A. W., Takahashi E. A. Merodiploid ribosomal loci arising by transformation and mutation in pneumococcus. J Bacteriol. 1970 Jan;101(1):38–52. doi: 10.1128/jb.101.1.38-52.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Sandler L, Hiraizumi Y, Sandler I. Meiotic Drive in Natural Populations of Drosophila Melanogaster. I. the Cytogenetic Basis of Segregation-Distortion. Genetics. 1959 Mar;44(2):233–250. doi: 10.1093/genetics/44.2.233. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES